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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

fimH  -  fimbrial adhesin FimH

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

 
 
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Disease relevance of fimH

  • Differential binding to and biofilm formation on, HEp-2 cells by Salmonella enterica serovar Typhimurium is dependent upon allelic variation in the fimH gene of the fim gene cluster [1].
 

High impact information on fimH

  • Characterization of the fimH genes, encoding the fimbrial adhesins, indicated two allelic variants [1].
  • Mutations in the fimH gene of Salmonella typhimurium result in a non-fimbriate, non-adhesive phenotype [2].
 

Biological context of fimH

  • Deletion mutations within the S. typhimurium fimH gene carried on a recombinant plasmid can be used to complement the mutant, and these transformants are non-adhesive but fully fimbriate, consistent with the role of FimH as being necessary for fimbrial adhesin expression [2].

References

  1. Differential binding to and biofilm formation on, HEp-2 cells by Salmonella enterica serovar Typhimurium is dependent upon allelic variation in the fimH gene of the fim gene cluster. Boddicker, J.D., Ledeboer, N.A., Jagnow, J., Jones, B.D., Clegg, S. Mol. Microbiol. (2002) [Pubmed]
  2. Construction and characterization of type 1 non-fimbriate and non-adhesive mutants of Salmonella typhimurium. Hancox, L.S., Yeh, K.S., Clegg, S. FEMS Immunol. Med. Microbiol. (1997) [Pubmed]
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