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Gene Review

csgD  -  DNA-binding transcriptional regulator CsgD

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of csgD

  • The starvation-induced csgD gene of Salmonella typhimurium encodes for the positive transcriptional regulator of extracellular matrix components curli fimbriae and cellulose [1].
  • These results indicate that MlrA is a newly defined transcriptional regulator of csgD/agfD that acts as a positive regulator of RpoS-dependent curli and extracellular matrix production by E. coli and S. typhimurium [2].

High impact information on csgD

  • In vitro transcription assays and potassium permanganate reactivity experiments with purified His(6)-Crl showed that Crl directly activated sigma(S)-dependent transcription initiation at the csgD and adrA promoters [3].
  • In this study, the nucleo-protein complex of PcsgD was extended through characterization of additional OmpR and IHF binding sites that influence the transcriptional activity of the csgD promoter [4].
  • Serovar-specific regulation of csgD required rpoS in S [5].
  • Enteritidis strains from human disease, food and animals expressed the rdar morphotype at 28 degrees C. Regulation of the rdar morphotype occurred via the response regulator ompR, which activated transcription of csgD required for production of cellulose and curli fimbriae [5].


  1. Complex regulation of csgD promoter activity by global regulatory proteins. Gerstel, U., Park, C., Römling, U. Mol. Microbiol. (2003) [Pubmed]
  2. MlrA, a novel regulator of curli (AgF) and extracellular matrix synthesis by Escherichia coli and Salmonella enterica serovar Typhimurium. Brown, P.K., Dozois, C.M., Nickerson, C.A., Zuppardo, A., Terlonge, J., Curtiss, R. Mol. Microbiol. (2001) [Pubmed]
  3. Crl activates transcription initiation of RpoS-regulated genes involved in the multicellular behavior of Salmonella enterica serovar Typhimurium. Robbe-Saule, V., Jaumouillé, V., Prévost, M.C., Guadagnini, S., Talhouarne, C., Mathout, H., Kolb, A., Norel, F. J. Bacteriol. (2006) [Pubmed]
  4. Regulatory components at the csgD promoter--additional roles for OmpR and integration host factor and role of the 5' untranslated region. Gerstel, U., Kolb, A., Römling, U. FEMS Microbiol. Lett. (2006) [Pubmed]
  5. Occurrence and regulation of the multicellular morphotype in Salmonella serovars important in human disease. Römling, U., Bokranz, W., Rabsch, W., Zogaj, X., Nimtz, M., Tschäpe, H. Int. J. Med. Microbiol. (2003) [Pubmed]
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