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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

trpB  -  tryptophan synthase subunit beta

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

 
 
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Disease relevance of trpB

  • The anthranilate-5-phosphoribosylpyrophosphate phosphoribosyltransferases (PRT), coded by the second structural gene (trpB) of the tryptophan (trp) operon in strains LT2 and LT7 of Salmonella typhimurium, differ from each other in a number of parameters [1].
 

High impact information on trpB

  • Tryptophan biosynthesis in Salmonella typhimurium: location in trpB of a genetic difference between strains LT2 and LT7 [2].
  • This strain difference was cryptic insofar as it did not affect the growth rate; it was revealed only as a rate-limiting step in the constitutive biosynthesis of tryptophan in the presence of anthranilic acid, and was due to a lesion in the LT7-derived trpB gene [2].
  • The trpB gene contains two exons separated by an intron of 105 nt, which is located close to the 5' end of the ORF [3].
 

Associations of trpB with chemical compounds

  • A knockout mutant for trpB displays tryptophan auxotrophy, no trpB transcript is detectable, and development is perturbed to an extent that is dependent on the amount of tryptophan added to the medium [3].

References

  1. Differences between the anthranilate-5-phosphoribosylpyrophosphate phosphoribosyltransferases of Salmonella typhimurium strains LT2 and LT7. Dooley, M., Torget, R., Balbinder, E. J. Gen. Microbiol. (1979) [Pubmed]
  2. Tryptophan biosynthesis in Salmonella typhimurium: location in trpB of a genetic difference between strains LT2 and LT7. Stuttard, C. J. Bacteriol. (1975) [Pubmed]
  3. The tryptophan synthase-encoding trpB gene of Aspergillus nidulans is regulated by the cross-pathway control system. Eckert, S.E., Kübler, E., Hoffmann, B., Braus, G.H. Mol. Gen. Genet. (2000) [Pubmed]
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