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Gene Review:

fliD - flagellar hook-associated protein 2

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Givens, J.R. et al., Yokoseki, T. et al., Kutsukake, K. et al., Ikeda, T. et al.

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Disease relevance of fliD

Negative regulation by fliD, fliS, and fliT of the export of the flagellum-specific anti-sigma factor, FlgM, in Salmonella typhimurium [1].

High impact information on fliD

Here, we have characterized the mechanism of transcription initiation by a holoenzyme carrying sigma(28) at the fliD and flgM promoters to determine if the mechanism of initiation observed at pfliC is a general phenomenon for all sigma(28)-dependent promoters [2].
In this study, using gene-disruption mutants in the individual genes in the fliD operon, we showed that mutations in any one of the genes in the operon enhanced both FlgM export and the expression of flagellar regulon [1].
Primer extension analysis indicated that the promoter region of fliD contains both class 2 and class 3 promoters, while that of flgK contains only a class 3 promoter [3].
The mutant deficient in the HAP2 structural gene (fliD) of Salmonella typhimurium has flagella composed of only hook-HAP1-HAP3 and excretes flagellin monomers into the culture medium [4].

References

Negative regulation by fliD, fliS, and fliT of the export of the flagellum-specific anti-sigma factor, FlgM, in Salmonella typhimurium. Yokoseki, T., Iino, T., Kutsukake, K. J. Bacteriol. (1996) [Pubmed]
Formation of intermediate transcription initiation complexes at pfliD and pflgM by sigma(28) RNA polymerase. Givens, J.R., McGovern, C.L., Dombroski, A.J. J. Bacteriol. (2001) [Pubmed]
Transcriptional analysis of the flgK and fliD operons of Salmonella typhimurium which encode flagellar hook-associated proteins. Kutsukake, K., Ide, N. Mol. Gen. Genet. (1995) [Pubmed]
Flagellar growth in a filament-less Salmonella fliD mutant supplemented with purified hook-associated protein 2. Ikeda, T., Yamaguchi, S., Hotani, H. J. Biochem. (1993) [Pubmed]

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