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Gene Review

eutR  -  HTH-type transcriptional regulator EutR

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of eutR

  • Mutants of rhiT from E. chrysanthemi (rhiT::Tn5), and an eutR homolog from Salmonella typhimurium (eutR::TnS) showed decreased ability to cause systemic inva sion on African violet [1].

High impact information on eutR

  • Previous genetic analysis revealed six eut genes that are needed for aerobic use of ethanolamine; one (eutR), encodes a positive regulator which mediates induction of the operon by vitamin B12 plus ethanolamine [2].
  • Because of this mode of regulation, constitutive regulatory mutations, described here, include mutations that generate new internal promoters and thereby increase the basal level of eutR gene expression [3].

Biological context of eutR

  • Evidence is presented that the placement of the eutR regulatory gene within the operon provides a means of balancing the competition between lyase and the regulatory protein for a very small pool of Ado-B12 [4].

Associations of eutR with chemical compounds

  • The eutR gene encodes a protein that activates transcription of the eut operon in response to the simultaneous presence of B12 and ethanolamine [3].


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