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Gene Review

ratB  -  outer membrane protein

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

 
 
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Disease relevance of ratB

  • DNA hybridization analysis revealed that the CS54 island is comprised of two regions with distinct phylogenetic distribution within the genus SALMONELLA: Homologues of shdA and ratB were detected only in serotypes of Salmonella enterica subsp [1].
 

High impact information on ratB

  • The shdA and ratB deletion strains exhibited a shedding defect in mice, whereas the sivH deletion strain was shed at numbers similar to the wild type [1].
  • A strain containing a deletion in the ratB gene exhibited a defect for the colonization of the cecum but not of the Peyer's patches, mesenteric lymph nodes, and spleen [1].

References

  1. Molecular and phenotypic analysis of the CS54 island of Salmonella enterica serotype typhimurium: identification of intestinal colonization and persistence determinants. Kingsley, R.A., Humphries, A.D., Weening, E.H., De Zoete, M.R., Winter, S., Papaconstantinopoulou, A., Dougan, G., Bäumler, A.J. Infect. Immun. (2003) [Pubmed]
 
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