The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Peyer's Patches

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Peyer's Patches


High impact information on Peyer's Patches


Chemical compound and disease context of Peyer's Patches


Biological context of Peyer's Patches


Anatomical context of Peyer's Patches

  • Initiation of nasopharyngeal-associated lymphoid tissue (NALT) development is independent of the programmed cytokine cascade necessary for the formation of Peyer's patches (PP) and peripheral lymph nodes (PLN), a cytokine cascade which consists of IL-7R, LTalpha1beta2/LTbetaR, and NIK [21].
  • Here, we demonstrate that in mice lacking the chemokine receptor CCR6, dendritic cells expressing CD11c and CD11b are absent from the subepithelial dome of Peyer's patches [22].
  • Salmonella breached the M cell barrier of casp-1(-/)- mice efficiently; however, there was a decrease in the number of apoptotic cells, intracellular bacteria, and the recruitment of polymorphonuclear lymphocytes in the Peyer's patches (PP) as compared with wild-type mice [1].
  • Evidence for a mature B cell subpopulation in Peyer's patches of young adult xid mice [23].
  • We successfully cloned antigen-specific T cells from murine gut-associated lymphoreticular tissue, i.e., Peyer's patches, which are dependent upon T cell growth factor and independent of antigen for continuous growth [24].

Associations of Peyer's Patches with chemical compounds


Gene context of Peyer's Patches


Analytical, diagnostic and therapeutic context of Peyer's Patches


  1. Salmonella exploits caspase-1 to colonize Peyer's patches in a murine typhoid model. Monack, D.M., Hersh, D., Ghori, N., Bouley, D., Zychlinsky, A., Falkow, S. J. Exp. Med. (2000) [Pubmed]
  2. Induction of colitis in mice deficient of Peyer's patches and mesenteric lymph nodes is associated with increased disease severity and formation of colonic lymphoid patches. Spahn, T.W., Herbst, H., Rennert, P.D., Lügering, N., Maaser, C., Kraft, M., Fontana, A., Weiner, H.L., Domschke, W., Kucharzik, T. Am. J. Pathol. (2002) [Pubmed]
  3. Transportation of prion protein across the intestinal mucosa of scrapie-susceptible and scrapie-resistant sheep. Jeffrey, M., González, L., Espenes, A., Press, C.M., Martin, S., Chaplin, M., Davis, L., Landsverk, T., MacAldowie, C., Eaton, S., McGovern, G. J. Pathol. (2006) [Pubmed]
  4. Ingestion of Giardia lamblia trophozoites by murine Peyer's patch macrophages. Hill, D.R., Pohl, R. Infect. Immun. (1990) [Pubmed]
  5. Immunofluorescence analysis of poliovirus receptor expression in Peyer's patches of humans, primates, and CD155 transgenic mice: implications for poliovirus infection. Iwasaki, A., Welker, R., Mueller, S., Linehan, M., Nomoto, A., Wimmer, E. J. Infect. Dis. (2002) [Pubmed]
  6. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Förster, R., Mattis, A.E., Kremmer, E., Wolf, E., Brem, G., Lipp, M. Cell (1996) [Pubmed]
  7. L-selectin-mediated lymphocyte rolling on MAdCAM-1. Berg, E.L., McEvoy, L.M., Berlin, C., Bargatze, R.F., Butcher, E.C. Nature (1993) [Pubmed]
  8. Requirement for RORgamma in thymocyte survival and lymphoid organ development. Sun, Z., Unutmaz, D., Zou, Y.R., Sunshine, M.J., Pierani, A., Brenner-Morton, S., Mebius, R.E., Littman, D.R. Science (2000) [Pubmed]
  9. Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues. Tumanov, A., Kuprash, D., Lagarkova, M., Grivennikov, S., Abe, K., Shakhov, A., Drutskaya, L., Stewart, C., Chervonsky, A., Nedospasov, S. Immunity (2002) [Pubmed]
  10. Different cytokines induce surface lymphotoxin-alphabeta on IL-7 receptor-alpha cells that differentially engender lymph nodes and Peyer's patches. Yoshida, H., Naito, A., Inoue, J., Satoh, M., Santee-Cooper, S.M., Ware, C.F., Togawa, A., Nishikawa, S., Nishikawa, S. Immunity (2002) [Pubmed]
  11. Enteric reovirus infection as a probe to study immunotoxicity of the gastrointestinal tract. Cuff, C.F., Fulton, J.R., Barnett, J.B., Boyce, C.S. Toxicol. Sci. (1998) [Pubmed]
  12. Immunization of mice with Salmonella typhimurium C5 aroA expressing a genetically toxoided derivative of the pneumococcal toxin pneumolysin. Paton, J.C., Morona, J.K., Harrer, S., Hansman, D., Morona, R. Microb. Pathog. (1993) [Pubmed]
  13. The novel immunosuppressant FTY720 induces peripheral lymphodepletion of both T- and B-cells in cynomolgus monkeys when given alone, with Cyclosporine Neoral or with RAD. Quesniaux, V.F., Menninger, K., Kunkler, A., Vedrine, C., Bernhard, M., Hedinger, R., Kraus, G., Schuurman, H.J. Transpl. Immunol. (2000) [Pubmed]
  14. Peroxidase-antiperoxidase and immunogold labeling of Salmonella typhimurium and Salmonella choleraesuis var kunzendorf in tissues of experimentally infected swine. Pospischil, A., Wood, R.L., Anderson, T.D. Am. J. Vet. Res. (1990) [Pubmed]
  15. Petechial hemorrhages in the small intestinal Peyer's patches: a new manifestation of systemic anaphylaxis. Levine, S., Saltzman, A. Immunol. Invest. (1998) [Pubmed]
  16. Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor. Neumann, B., Luz, A., Pfeffer, K., Holzmann, B. J. Exp. Med. (1996) [Pubmed]
  17. Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes. González-Fernández, A., Milstein, C. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  18. The lpf fimbrial operon mediates adhesion of Salmonella typhimurium to murine Peyer's patches. Bäumler, A.J., Tsolis, R.M., Heffron, F. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  19. DR5 knockout mice are compromised in radiation-induced apoptosis. Finnberg, N., Gruber, J.J., Fei, P., Rudolph, D., Bric, A., Kim, S.H., Burns, T.F., Ajuha, H., Page, R., Wu, G.S., Chen, Y., McKenna, W.G., Bernhard, E., Lowe, S., Mak, T., El-Deiry, W.S. Mol. Cell. Biol. (2005) [Pubmed]
  20. Antitumor effect of beta2-microglobulin in leukemic cell-bearing mice via apoptosis-inducing activity: activation of caspase-3 and nuclear factor-kappaB. Mori, M., Terui, Y., Tanaka, M., Tomizuka, H., Mishima, Y., Ikeda, M., Kasahara, T., Uwai, M., Ueda, M., Inoue, R., Itoh, T., Yamada, M., Hayasawa, H., Furukawa, Y., Ishizaka, Y., Ozawa, K., Hatake, K. Cancer Res. (2001) [Pubmed]
  21. Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells. Fukuyama, S., Hiroi, T., Yokota, Y., Rennert, P.D., Yanagita, M., Kinoshita, N., Terawaki, S., Shikina, T., Yamamoto, M., Kurono, Y., Kiyono, H. Immunity (2002) [Pubmed]
  22. CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Cook, D.N., Prosser, D.M., Forster, R., Zhang, J., Kuklin, N.A., Abbondanzo, S.J., Niu, X.D., Chen, S.C., Manfra, D.J., Wiekowski, M.T., Sullivan, L.M., Smith, S.R., Greenberg, H.B., Narula, S.K., Lipp, M., Lira, S.A. Immunity (2000) [Pubmed]
  23. Evidence for a mature B cell subpopulation in Peyer's patches of young adult xid mice. Eldridge, J.H., Kiyono, H., Michalek, S.M., McGhee, J.R. J. Exp. Med. (1983) [Pubmed]
  24. Murine Peyer's patch T cell clones. Characterization of antigen-specific helper T cells for immunoglobulin A responses. Kiyono, H., McGhee, J.R., Mosteller, L.M., Eldridge, J.H., Koopman, W.J., Kearney, J.F., Michalek, S.M. J. Exp. Med. (1982) [Pubmed]
  25. Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process. Frey, S., Bertocci, B., Delbos, F., Quint, L., Weill, J.C., Reynaud, C.A. Immunity (1998) [Pubmed]
  26. Luminal lymphoid cells in the rabbit intestine. Heatley, R.V., Bienenstock, J. Gastroenterology (1982) [Pubmed]
  27. Altered jejunal permeability to macromolecules during viral enteritis in the piglet. Keljo, D.J., Butler, D.G., Hamilton, J.R. Gastroenterology (1985) [Pubmed]
  28. Requirement for sialic acid on the endothelial ligand of a lymphocyte homing receptor. True, D.D., Singer, M.S., Lasky, L.A., Rosen, S.D. J. Cell Biol. (1990) [Pubmed]
  29. Cloning and expression of mouse integrin beta p(beta 7): a functional role in Peyer's patch-specific lymphocyte homing. Hu, M.C., Crowe, D.T., Weissman, I.L., Holzmann, B. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  30. Eosinophilia in transgenic mice expressing interleukin 5. Dent, L.A., Strath, M., Mellor, A.L., Sanderson, C.J. J. Exp. Med. (1990) [Pubmed]
  31. Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis. Honda, K., Nakano, H., Yoshida, H., Nishikawa, S., Rennert, P., Ikuta, K., Tamechika, M., Yamaguchi, K., Fukumoto, T., Chiba, T., Nishikawa, S.I. J. Exp. Med. (2001) [Pubmed]
  32. Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I. Matsushima, A., Kaisho, T., Rennert, P.D., Nakano, H., Kurosawa, K., Uchida, D., Takeda, K., Akira, S., Matsumoto, M. J. Exp. Med. (2001) [Pubmed]
  33. A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication. Kuwahara, K., Yoshida, M., Kondo, E., Sakata, A., Watanabe, Y., Abe, E., Kouno, Y., Tomiyasu, S., Fujimura, S., Tokuhisa, T., Kimura, H., Ezaki, T., Sakaguchi, N. Blood (2000) [Pubmed]
  34. Preferential location of somatostatin receptors in germinal centers of human gut lymphoid tissue. Reubi, J.C., Horisberger, U., Waser, B., Gebbers, J.O., Laissue, J. Gastroenterology (1992) [Pubmed]
  35. Use of a Clostridium perfringens vector to express high levels of SIV p27 protein for the development of an oral SIV vaccine. Chen, Y., Helmus, R., McClane, B., Hoffman, R., Watkins, S., Wehrli, T., Gupta, P. Virology (2004) [Pubmed]
  36. Comparison of poly(DL-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M cells. Jepson, M.A., Simmons, N.L., O'Hagan, D.T., Hirst, B.H. Journal of drug targeting. (1993) [Pubmed]
  37. In vivo uptake of chitosan microparticles by murine Peyer's patches: visualization studies using confocal laser scanning microscopy and immunohistochemistry. Van Der Lubben, I.M., Konings, F.A., Borchard, G., Verhoef, J.C., Junginger, H.E. Journal of drug targeting. (2001) [Pubmed]
  38. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats, III. Increase in frequency of CD62L-positive T cells in Peyer's patches by FTY720-induced lymphocyte homing. Yanagawa, Y., Masubuchi, Y., Chiba, K. Immunology (1998) [Pubmed]
WikiGenes - Universities