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Gene Review: 

sicA  -  chaperone protein SicA

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

 
 
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Disease relevance of sicA

  • The introduction of plasmids encoding invF and sicA into a non-pathogenic E. coli K-12 strain stimulated the transcription of both a sicA- and a sigD-lacZYA promoter fusion [1].
  • An additional gene was identified, sicA, which encodes a protein homologous to IpgC, a Shigella protein that serves as a molecular chaperone for the invasins IpaB and IpaC [2].
 

High impact information on sicA

  • This functional difference is not at the level of secretion because IpaC and SipC are both secreted by SF621 and it does not appear to be because of SipC dependency on this native chaperone as coexpression of sipC and sicA in SF621 still failed to restore detectable invasiveness [3].
  • The regulation defect of the spaS mutant was complemented by sicA and not by spaS [1].
 

Other interactions of sicA

  • This is the first demonstration that there is a functional promoter in the intergenic sequence between spaS and sicA [4].

References

  1. The putative invasion protein chaperone SicA acts together with InvF to activate the expression of Salmonella typhimurium virulence genes. Darwin, K.H., Miller, V.L. Mol. Microbiol. (2000) [Pubmed]
  2. Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells. Kaniga, K., Tucker, S., Trollinger, D., Galán, J.E. J. Bacteriol. (1995) [Pubmed]
  3. IpaC from Shigella and SipC from Salmonella possess similar biochemical properties but are functionally distinct. Osiecki, J.C., Barker, J., Picking, W.L., Serfis, A.B., Berring, E., Shah, S., Harrington, A., Picking, W.D. Mol. Microbiol. (2001) [Pubmed]
  4. InvF is required for expression of genes encoding proteins secreted by the SPI1 type III secretion apparatus in Salmonella typhimurium. Darwin, K.H., Miller, V.L. J. Bacteriol. (1999) [Pubmed]
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