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Gene Review

sicA  -  chaperone protein SicA

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of sicA

  • The introduction of plasmids encoding invF and sicA into a non-pathogenic E. coli K-12 strain stimulated the transcription of both a sicA- and a sigD-lacZYA promoter fusion [1].
  • An additional gene was identified, sicA, which encodes a protein homologous to IpgC, a Shigella protein that serves as a molecular chaperone for the invasins IpaB and IpaC [2].

High impact information on sicA

  • This functional difference is not at the level of secretion because IpaC and SipC are both secreted by SF621 and it does not appear to be because of SipC dependency on this native chaperone as coexpression of sipC and sicA in SF621 still failed to restore detectable invasiveness [3].
  • The regulation defect of the spaS mutant was complemented by sicA and not by spaS [1].

Other interactions of sicA

  • This is the first demonstration that there is a functional promoter in the intergenic sequence between spaS and sicA [4].


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