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Gene Review

sipC  -  cell invasion protein SipC

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of sipC

  • Interestingly, whereas SB220 expressing sipC behaved like wild-type Salmonella, in that it remained within its membrane-bound vacuole following entry into host cells, SB220 expressing ipaC was found in the cytoplasm of host cells [1].

High impact information on sipC

  • This functional difference is not at the level of secretion because IpaC and SipC are both secreted by SF621 and it does not appear to be because of SipC dependency on this native chaperone as coexpression of sipC and sicA in SF621 still failed to restore detectable invasiveness [1].
  • To extend these observations, complementation analyses were conducted using S. flexneri SF621 and S. typhimurium SB220, neither of which is capable of invading epithelial cells because of non-polar null mutations in ipaC and sipC respectively [1].
  • We further found, however, that CsrA could affect the expression of both invF and sipC independent of its effects on hilA [2].
  • The genes encoding these proteins are located at centisome 63 on the S. typhimurium chromosome, immediately downstream of the previously identified sipB and sipC genes (K. Kaniga, S. Tucker, D. Trollinger, and J. E. Galán, J. Bacteriol. 177:3965-3971, 1995) [3].


  1. IpaC from Shigella and SipC from Salmonella possess similar biochemical properties but are functionally distinct. Osiecki, J.C., Barker, J., Picking, W.L., Serfis, A.B., Berring, E., Shah, S., Harrington, A., Picking, W.D. Mol. Microbiol. (2001) [Pubmed]
  2. Regulation of Salmonella enterica serovar typhimurium invasion genes by csrA. Altier, C., Suyemoto, M., Lawhon, S.D. Infect. Immun. (2000) [Pubmed]
  3. Identification of two targets of the type III protein secretion system encoded by the inv and spa loci of Salmonella typhimurium that have homology to the Shigella IpaD and IpaA proteins. Kaniga, K., Trollinger, D., Galán, J.E. J. Bacteriol. (1995) [Pubmed]
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