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Gene Review

invC  -  ATP synthase SpaL

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

 
 
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Disease relevance of invC

  • Molecular and functional characterization of the Salmonella typhimurium invasion genes invB and invC: homology of InvC to the F0F1 ATPase family of proteins [1].
 

High impact information on invC

  • Invasion-defective invC and invG mutants of S. typhimurium failed to secrete InvJ upon contact with live Henle-407 cells [2].
  • A mutation in invC rendered S. typhimurium defective in their ability to enter cultured epithelial cells, while mutations in invB did not [1].
 

Biological context of invC

 

Analytical, diagnostic and therapeutic context of invC

  • Site-directed mutagenesis of a residue essential for the catalytical function of this family of proteins resulted in a protein devoid of ATPase activity and unable to complement an invC mutant of S. typhimurium [1].

References

 
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