The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

invG  -  invasion protein InvG

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of invG

  • The Salmonella typhimurium invasion genes invF and invG encode homologues of the AraC and PulD family of proteins [1].

High impact information on invG

  • Mutations in invG and invC, two members of the Salmonella inv locus, effectively prevented the transport of InvJ to the culture supernatant [2].
  • We have found that strains containing a mutation in hilA or invG were recovered from the intestinal contents, intestinal tissues, and systemic tissues at a lower frequency than their parental wild-type strain [3].
  • Invasion-deficient S. typhimurium strains carrying mutations in components of SPI1 (invA, invG, sspC, and prgH) exhibited filamentous appendages similar to those on wild-type S. typhimurium when adhering to epithelial cells, demonstrating that formation of these appendages is not itself sufficient to trigger bacterial invasion [4].
  • In this study, we show that mutants possessing defects in one of two inv genes, invA or invG, which render them severely deficient for invasion of polarized epithelial MDCK cells, retain their ability to actively invade mouse Peyer's patch M cells [5].
  • The mutations were found to be insertions in two previously identified invasion genes, invG and invH, and in a gene not normally associated with invasion, pagC [6].

Biological context of invG


  1. The Salmonella typhimurium invasion genes invF and invG encode homologues of the AraC and PulD family of proteins. Kaniga, K., Bossio, J.C., Galán, J.E. Mol. Microbiol. (1994) [Pubmed]
  2. Functional analysis of the Salmonella typhimurium invasion genes invl and invJ and identification of a target of the protein secretion apparatus encoded in the inv locus. Collazo, C.M., Zierler, M.K., Galán, J.E. Mol. Microbiol. (1995) [Pubmed]
  3. Invasion genes are not required for Salmonella enterica serovar typhimurium to breach the intestinal epithelium: evidence that salmonella pathogenicity island 1 has alternative functions during infection. Murray, R.A., Lee, C.A. Infect. Immun. (2000) [Pubmed]
  4. Cell-contact-stimulated formation of filamentous appendages by Salmonella typhimurium does not depend on the type III secretion system encoded by Salmonella pathogenicity island 1. Reed, K.A., Clark, M.A., Booth, T.A., Hueck, C.J., Miller, S.I., Hirst, B.H., Jepson, M.A. Infect. Immun. (1998) [Pubmed]
  5. Invasion of murine intestinal M cells by Salmonella typhimurium inv mutants severely deficient for invasion of cultured cells. Clark, M.A., Reed, K.A., Lodge, J., Stephen, J., Hirst, B.H., Jepson, M.A. Infect. Immun. (1996) [Pubmed]
  6. Biological and genetic characterization of TnphoA mutants of Salmonella typhimurium TML in the context of gastroenteritis. Lodge, J., Douce, G.R., Amin, I.I., Bolton, A.J., Martin, G.D., Chatfield, S., Dougan, G., Brown, N.L., Stephen, J. Infect. Immun. (1995) [Pubmed]
WikiGenes - Universities