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Gene Review:

recJ - ssDNA-specific exonuclease RecJ

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Garzón, A. et al., Miesel, L. et al.

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Disease relevance of recJ

A role for the RecF, RecJ, and SbcB proteins in the RecBCD-dependent recombination pathway is suggested on the basis of the effect of null recF, recJ, and sbcB mutations in Salmonella typhimurium on a "short-homology" P22 transduction assay [1].

High impact information on recJ

In a standard transduction assay (about 20 kb of flanking sequence), recF, recJ, and sbcB mutations have a very small effect on recombinant frequency [1].
Plasmids remain unstable in recA recD recJ mutants; since these do not produce HMW linear concatemers, we propose that a decrease in monomer production leads to plasmid instability. recB recJ strains also display decreased viability, a component of which may be related to their deficiency in DNA repair [2].

References

Evidence that SbcB and RecF pathway functions contribute to RecBCD-dependent transductional recombination. Miesel, L., Roth, J.R. J. Bacteriol. (1996) [Pubmed]
recB recJ mutants of Salmonella typhimurium are deficient in transductional recombination, DNA repair and plasmid maintenance. Garzón, A., Beuzón, C.R., Mahan, M.J., Casadesús, J. Mol. Gen. Genet. (1996) [Pubmed]

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