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Gene Review:

recB - exonuclease V subunit beta

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Garzón, A. et al., Mahan, M.J. et al., Sonti, R.V. et al., Garí, E. et al., Segall, A.M. et al.

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Disease relevance of recB

However when the same MudI phage is injected by a phage P22 virion, lysogeny is reduced in a recA or recB mutant host [1].
recB and recC genes of Salmonella typhimurium [2].

High impact information on recB

Such mutations also restore SOS induction in quinolone-treated gyr+ recB- strains [3].
(c) Both recA and recB mutations eliminate inversion formation [4].
We have investigated the genetic organization of the recB (exonuclease V) and recC (exonuclease V) genes of Salmonella typhimurium [2].
In contrast to their severe defects in recombination, DNA repair and plasmid maintenance, recB recJ mutants of S. typhimurium behave similarly to the wild type in the segregation of chromosome duplications [5].
recB recJ mutants of Salmonella typhimurium are deficient in transduction of chromosomal markers and ColE1-derived plasmids, and also in the maintenance of ColE1 and F plasmids [5].

Biological context of recB

A detailed genetic map is constructed that includes the relative order in the chromosome, P22 cotransduction frequencies, and the orientation of transcription of the recB and recC genes [2].

References

Lethal transposition of Mud phages in Rec- strains of Salmonella typhimurium. Sonti, R.V., Keating, D.H., Roth, J.R. Genetics (1993) [Pubmed]
recB and recC genes of Salmonella typhimurium. Mahan, M.J., Roth, J.R. J. Bacteriol. (1989) [Pubmed]
A class of gyrase mutants of Salmonella typhimurium show quinolone-like lethality and require rec functions for viability. Garí, E., Figueroa-Bossi, N., Blanc-Potard, A.B., Spirito, F., Schmid, M.B., Bossi, L. Mol. Microbiol. (1996) [Pubmed]
Approaches to half-tetrad analysis in bacteria: recombination between repeated, inverse-order chromosomal sequences. Segall, A.M., Roth, J.R. Genetics (1994) [Pubmed]
recB recJ mutants of Salmonella typhimurium are deficient in transductional recombination, DNA repair and plasmid maintenance. Garzón, A., Beuzón, C.R., Mahan, M.J., Casadesús, J. Mol. Gen. Genet. (1996) [Pubmed]

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