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Gene Review

oxyR  -  DNA-binding transcriptional regulator OxyR

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of oxyR


High impact information on oxyR

  • Comparison of the sensitivities of Salmonella typhimurium oxyR and katG mutants to killing by human neutrophils [2].
  • We have tested this possibility by comparing the survival, following exposure to human neutrophils, of isogenic strains bearing different oxyR alleles [2].
  • Some researchers have suggested that oxyR may play a key role in bacterial survival following phagocytosis [2].
  • The oxyR-dependent induction is suppressed under conditions that accelerate the Fenton reaction by a mechanism that is not yet understood [3].

Regulatory relationships of oxyR


  1. Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium. Christman, M.F., Morgan, R.W., Jacobson, F.S., Ames, B.N. Cell (1985) [Pubmed]
  2. Comparison of the sensitivities of Salmonella typhimurium oxyR and katG mutants to killing by human neutrophils. Papp-Szabò, E., Firtel, M., Josephy, P.D. Infect. Immun. (1994) [Pubmed]
  3. A Salmonella enterica serovar typhimurium hemA mutant is highly susceptible to oxidative DNA damage. Elgrably-Weiss, M., Park, S., Schlosser-Silverman, E., Rosenshine, I., Imlay, J., Altuvia, S. J. Bacteriol. (2002) [Pubmed]
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