Disease relevance of oxyR

• The oxyR regulatory network is a previously uncharacterized global regulatory system in enteric bacteria [1].
• The oxyR gene of Salmonella typhimurium controls a regulon induced by oxidative stress, such as exposure to hydrogen peroxide [2].

High impact information on oxyR

• Comparison of the sensitivities of Salmonella typhimurium oxyR and katG mutants to killing by human neutrophils [2].
• We have tested this possibility by comparing the survival, following exposure to human neutrophils, of isogenic strains bearing different oxyR alleles [2].
• Some researchers have suggested that oxyR may play a key role in bacterial survival following phagocytosis [2].
• The oxyR-dependent induction is suppressed under conditions that accelerate the Fenton reaction by a mechanism that is not yet understood [3].

Regulatory relationships of oxyR

• The katG gene, encoding the oxyR-regulated enzyme hydroperoxidase I, was also without effect on survival following exposure to neutrophils [2].

References