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Gene Review

30.8  -  gp30.8 conserved hypothetical protein

Enterobacteria phage T4

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Disease relevance of 30.8

  • Gp9, which has an M(r) of 30.8 kDa and contains 287 amino acids, has been purified from a recombinant Escherichia coli strain and crystallized at 25 degrees C using the hanging drop vapor diffusion method at pH 4.0 with ammonium sulfate as precipitant [1].
  • METHODS: A total of 176 procedures (91 patients) were carried out in the ETS 2-4 group and 103 procedures (53 patients) in the ESB 4 group: 60.4 and 43.4% had palmar hyperhidrosis, 8.8 and 5.7% had isolated axillary, and 30.8 and 50.9% had combined manifestations, respectively [2].

High impact information on 30.8

  • In agreement with this assignment, two strong T4 early promoters, P(E )30.8 (128.6) and P(E )30.7 (128.2), located about 3.1 and 2.7 kb upstream from gene 30 have been revealed by promoter mapping and sequence analysis [3].
  • After cimetidine had been given for 3-5 weeks there was a significant decrease, compared with pretreatment numbers, in the proportion of T3+ cells (64.6 +/- 8.1 (mean +/- s.d.) v 51.0 +/- 7.8%) and in T4+ cells (47.3 +/- 4.3 v 30.8 +/- 4.7%) [4].
  • The binding capacity of serum thyroxine-binding globulin was greater in female rats than in male rats (27 +/- 1.3 vs 18.0 +/- 1.3 nmol/l, p less than 0.01) and in fasted female rats than in fasted male rats (64.4 +/- 2.6 vs 30.8 +/- 2.7 nmol/l, p less than 0.01) [5].


  1. Crystallization and preliminary crystallographic characterization of bacteriophage T4 baseplate protein encoded by gene 9. Strelkov, S.V., Zurabishvili, T.G., Nepluev, I.V., Efimov, V.P., Isupov, M.N., Harutyunyan, E.H., Mesyanzhinov, V.V. J. Mol. Biol. (1993) [Pubmed]
  2. Limited endoscopic thoracic sympathetic block for hyperhidrosis of the upper limb: reduction of compensatory sweating by clipping T4. Neumayer, C., Zacherl, J., Holak, G., Függer, R., Jakesz, R., Herbst, F., Bischof, G. Surgical endoscopy. (2004) [Pubmed]
  3. Identification of two middle promoters upstream DNA ligase gene 30 of bacteriophage T4. Truncaite, L., Zajanckauskaite, A., Nivinskas, R. J. Mol. Biol. (2002) [Pubmed]
  4. Decrease in helper (T4+) lymphocytes following cimetidine treatment for duodenal ulcer. Hast, R., Bernell, P., Befrits, R., Dowding, C., Sjögren, A.M. Clin. Exp. Immunol. (1986) [Pubmed]
  5. Gender-related differences of serum thyroxine-binding proteins in the rat. Emerson, C.H., Cohen, J.H., Young, R.A., Alex, S., Fang, S.L. Acta Endocrinol. (1990) [Pubmed]
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