The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

CD4-Positive T-Lymphocytes

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CD4-Positive T-Lymphocytes

  • Predictive markers for the acquired immunodeficiency syndrome (AIDS) in hemophiliacs: persistence of p24 antigen and low T4 cell count [1].
  • Other clinical and laboratory parameters such as p24 antigen, phytohemagglutinin mitogenic index, and absolute surface antigen T4+ cell counts did not accurately predict HIV fetal transmission [2].
  • A tetra-, penta- or nonaribozyme under control of the SV40 late promoter, the beta-actin gene promoter or the HIV-1 LTR, respectively, were cotransfected with the infectious HIV-1 DNA clone pNL4-3 into permissive HeLa T4 cells [3].
  • In this report, L and P proteins of the paramyxovirus simian virus 5 (SV5) were coexpressed in HeLa T4 cells from cDNA plasmids, and L-P complexes were examined [4].
  • In the present study we have further investigated the fusion properties of F and HN proteins of parainfluenza virus type 1 (PI1), type 2 (PI2), and type 3 (PI3), Sendai virus (SN), and simian virus 5 (SV5) by expression of their glycoprotein genes in HeLa T4 cells using the vaccinia virus-T7 transient expression system [5].

High impact information on CD4-Positive T-Lymphocytes

  • We report here that preincubation of T4+ lymphocytes with three individual monoclonal antibodies directed at the T4 glycoprotein blocked cell infection by LAV [6].
  • Here, we show that transfectants expressing HLA-DR7 and either B7 or intercellular adhesion molecule 1 (ICAM-1) deliver independent costimulatory signals resulting in alloantigen-induced proliferation of CD4-positive T lymphocytes [7].
  • Isolated T4+ cells ceased to respond to IL-2 well before T8+ cells, and before the disappearance of adequate levels of IL-2-R [8].
  • Accordingly, T4+ cell autocrine IL-2 responsiveness is restricted by a mechanism that is independent of IL-2-R, and which ultimately results in cessation of both T4+ and T8+ cell IL-2-dependent clonal expansion [8].
  • Since T4+ cells proliferate in an autocrine fashion to endogenous IL-2, whereas most T8+ cells respond in a paracrine fashion to IL-2 derived from T4+ cells, we thought it likely that a unique mechanism was operative to restrict T4+ cell IL-2-dependent autocrine proliferation [8].

Chemical compound and disease context of CD4-Positive T-Lymphocytes


Biological context of CD4-Positive T-Lymphocytes


Anatomical context of CD4-Positive T-Lymphocytes


Associations of CD4-Positive T-Lymphocytes with chemical compounds

  • Isoprinosine and Imuthiol increased significantly both the percentage and the absolute number of T4+ cells when peripheral blood mononuclear cells were incubated for 4 days in RPMI supplemented with 10% fetal calf serum [23].
  • Despite the ability to present nominal antigen, paraformaldehyde-fixed AC were unable to induce allogeneic T4 cell proliferation [24].
  • These results suggest that LTB4 may regulate immune cell functions by inducing IFN-gamma production by T4+ cells [25].
  • CD40 is a member of the tumor necrosis factor (TNF) family of receptors whose ligand (CD154) is mainly expressed on the membrane of activated CD4-positive lymphocytes [26].
  • The response of highly enriched populations of human T8+ lymphocytes to the oxidative mitogenic enzymes neuraminidase (NA) and galactose oxidase (GO) was enhanced by NAGO-primed T4+ lymphocytes [27].

Gene context of CD4-Positive T-Lymphocytes

  • The capacity of the monoclonal antibodies (Mab) 64.1 and OKT3 directed at CD3 molecules to induce T4 cell proliferation and interleukin 2 (IL 2) production was examined [28].
  • Monoclonal antibodies against class II MHC (Ia) antigenic determinants blocked the AMLR between non-T cells and any of the above responder populations; in contrast, monoclonal anti-class I (HLA-A, B, C) antibodies inhibited the response of T8+ cells but not of isolated T4+ cells [29].
  • To change the coreceptor usage of this vector from CCR5 to CXCR4, which is predominant on human CD4-positive lymphocytes, the putative V3-loop of SIVagm SU was replaced by that of the T cell tropic HIV-1 variant BH10 [30].
  • The data indicate that in the absence of AC, a stimulatory matrix of immobilized 64.1 is sufficient for some T4 cells to be activated to become IL2 or IL4 responsive and for a smaller percentage to secrete IL2 [31].
  • The results suggest that eosinophilia was caused by IL-5 and GM-CSF production by rhIL-2 stimulated CD4 positive lymphocytes [32].

Analytical, diagnostic and therapeutic context of CD4-Positive T-Lymphocytes

  • In the control group, suppression mediated by T8+ cells exceeded that mediated by T4+ cells; such differences were not apparent in the MS group [33].
  • Association was also sought between CIN and immunosuppression, as measured clinically by T4 cell number, beta-2-microglobulin and p24 antigen [34].
  • Human peripheral T4 lymphocytes were obtained by venipuncture, propagated in RPMI 1640 medium and challenged with varied concentrations of aflatoxins, B1, B2, G1, and G2 [35].
  • The qualitative PCR was more sensitive than the p24 antigen assay but the presence of the latter was predictive of progression of infection as determined clinically and by falling T4 cell counts and rising levels of beta 2M [36].


  1. Predictive markers for the acquired immunodeficiency syndrome (AIDS) in hemophiliacs: persistence of p24 antigen and low T4 cell count. Eyster, M.E., Ballard, J.O., Gail, M.H., Drummond, J.E., Goedert, J.J. Ann. Intern. Med. (1989) [Pubmed]
  2. Vertical transmission of human immunodeficiency virus is correlated with the absence of high-affinity/avidity maternal antibodies to the gp120 principal neutralizing domain. Devash, Y., Calvelli, T.A., Wood, D.G., Reagan, K.J., Rubinstein, A. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  3. Multitarget-ribozyme directed to cleave at up to nine highly conserved HIV-1 env RNA regions inhibits HIV-1 replication--potential effectiveness against most presently sequenced HIV-1 isolates. Chen, C.J., Banerjea, A.C., Harmison, G.G., Haglund, K., Schubert, M. Nucleic Acids Res. (1992) [Pubmed]
  4. Mapping of a region of the paramyxovirus L protein required for the formation of a stable complex with the viral phosphoprotein P. Parks, G.D. J. Virol. (1994) [Pubmed]
  5. Association of the parainfluenza virus fusion and hemagglutinin-neuraminidase glycoproteins on cell surfaces. Yao, Q., Hu, X., Compans, R.W. J. Virol. (1997) [Pubmed]
  6. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Klatzmann, D., Champagne, E., Chamaret, S., Gruest, J., Guetard, D., Hercend, T., Gluckman, J.C., Montagnier, L. Nature (1984) [Pubmed]
  7. B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance. Boussiotis, V.A., Freeman, G.J., Gray, G., Gribben, J., Nadler, L.M. J. Exp. Med. (1993) [Pubmed]
  8. Regulation of T cell autocrine growth. T4+ cells become refractory to interleukin 2. Gullberg, M., Smith, K.A. J. Exp. Med. (1986) [Pubmed]
  9. Processing protease for gp160 human immunodeficiency virus type I envelope glycoprotein precursor in human T4+ lymphocytes. Purification and characterization. Kido, H., Kamoshita, K., Fukutomi, A., Katunuma, N. J. Biol. Chem. (1993) [Pubmed]
  10. Decrease in helper (T4+) lymphocytes following cimetidine treatment for duodenal ulcer. Hast, R., Bernell, P., Befrits, R., Dowding, C., Sjögren, A.M. Clin. Exp. Immunol. (1986) [Pubmed]
  11. Calmodulin antagonists inhibit human immunodeficiency virus-induced cell fusion but not virus replication. Srinivas, R.V., Bernstein, H., Oliver, C., Compans, R.W. AIDS Res. Hum. Retroviruses (1994) [Pubmed]
  12. Inhibition of tryptase TL2 from human T4+ lymphocytes and inhibition of HIV-1 replication in H9 cells by recombinant aprotinin and bikunin homologues. Brinkmann, T., Schäfers, J., Gürtler, L., Kido, H., Niwa, Y., Katunuma, N., Tschesche, H. J. Protein Chem. (1997) [Pubmed]
  13. Spatial structure model of the CD4 receptor-binding site of the HIV envelope protein gp120. Andrianov, A.M. J. Biomol. Struct. Dyn. (1998) [Pubmed]
  14. HLA haplotype A1 B8 DR3 as a risk factor for HIV-related disease. Steel, C.M., Ludlam, C.A., Beatson, D., Peutherer, J.F., Cuthbert, R.J., Simmonds, P., Morrison, H., Jones, M. Lancet (1988) [Pubmed]
  15. Peptide specificity of alloreactive CD4 positive T lymphocytes directed against a major histocompatibility complex class I disparity. Ossevoort, M.A., De Bruijn, M.L., Van Veen, K.J., Kast, W.M., Melief, C.J. Transplantation (1996) [Pubmed]
  16. Production of a non-functional nef protein in human immunodeficiency virus type 1-infected CEM cells. Laurent, A.G., Hovanessian, A.G., Rivière, Y., Krust, B., Regnault, A., Montagnier, L., Findeli, A., Kieny, M.P., Guy, B. J. Gen. Virol. (1990) [Pubmed]
  17. Glutathione homeostasis is disturbed in CD4-positive lymphocytes of HIV-seropositive individuals. van der Ven, A.J., Blom, H.J., Peters, W., Jacobs, L.E., Verver, T.J., Koopmans, P.P., Demacker, P., van der Meer, J.W. Eur. J. Clin. Invest. (1998) [Pubmed]
  18. A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody. Morimoto, C., Steinberg, A.D., Letvin, N.L., Hagan, M., Takeuchi, T., Daley, J., Levine, H., Schlossman, S.F. J. Clin. Invest. (1987) [Pubmed]
  19. Use of a monoclonal antibody (GA3) to demonstrate lineage restricted O-glycosylation on leukosialin during terminal erythroid differentiation. Bettaieb, A., Farace, F., Mitjavila, M.T., Mishal, Z., Dokhelar, M.C., Tursz, T., Breton-Gorius, J., Vainchenker, W., Kieffer, N. Blood (1988) [Pubmed]
  20. Phenotypic and functional heterogeneity of human peripheral blood T lymphocytes producing colony stimulating factor. A clonal and precursor frequency analysis. Pantaleo, G., Moretta, A., Cillo, C., Eliason, J.F., Moretta, L. J. Immunol. (1985) [Pubmed]
  21. Role of IL-2 in the generation of CD4+ suppressors of human B cell responsiveness. Hirohata, S., Davis, L.S., Lipsky, P.E. J. Immunol. (1989) [Pubmed]
  22. Lymphokine activation of T4+ T lymphocytes and monocytes. Cruikshank, W.W., Berman, J.S., Theodore, A.C., Bernardo, J., Center, D.M. J. Immunol. (1987) [Pubmed]
  23. Isoprinosine and Imuthiol, two potentially active compounds in patients with AIDS-related complex symptoms. Pompidou, A., Delsaux, M.C., Telvi, L., Mace, B., Coutance, F., Falkenrodt, A., Lang, J.M. Cancer Res. (1985) [Pubmed]
  24. Differential ability of fixed antigen-presenting cells to stimulate nominal antigen-reactive and alloreactive T4 lymphocytes. Moreno, J., Lipsky, P.E. J. Immunol. (1986) [Pubmed]
  25. Identification of interferon-gamma as the lymphokine that mediates leukotriene B4-induced immunoregulation. Rola-Pleszczynski, M., Bouvrette, L., Gingras, D., Girard, M. J. Immunol. (1987) [Pubmed]
  26. CD40 is expressed on human peritoneal mesothelial cells and upregulates the production of interleukin-15 and RANTES. Basok, A., Shnaider, A., Man, L., Chaimovitz, C., Douvdevani, A. J. Am. Soc. Nephrol. (2001) [Pubmed]
  27. The selective activation of T8+ cells by neuraminidase and galactose oxidase is mediated by activated T4+ cells. Akeson, A.L., Harmony, J.A. Exp. Cell Res. (1987) [Pubmed]
  28. Accessory cell independent proliferation of human T4 cells stimulated by immobilized monoclonal antibodies to CD3. Geppert, T.D., Lipsky, P.E. J. Immunol. (1987) [Pubmed]
  29. Surface molecules involved in self-recognition and T cell activation in the autologous mixed lymphocyte reaction. Romain, P.L., Schlossman, S.F., Reinherz, E.L. J. Immunol. (1984) [Pubmed]
  30. Coreceptor Switch of [MLV(SIVagm)] pseudotype vectors by V3-loop exchange. Steidl, S., Stitz, J., Schmitt, I., König, R., Flory, E., Schweizer, M., Cichutek, K. Virology (2002) [Pubmed]
  31. Precursor frequency of human T4 cells responding to stimulation through the CD3 molecular complex: role of various cytokines in promoting growth and IL2 production. Vine, J.B., Geppert, T.D., Lipsky, P.E. Cell. Immunol. (1989) [Pubmed]
  32. Interleukin-2 treatment-associated eosinophilia is mediated by interleukin-5 production. Macdonald, D., Gordon, A.A., Kajitani, H., Enokihara, H., Barrett, A.J. Br. J. Haematol. (1990) [Pubmed]
  33. Activated suppressor cell dysfunction in progressive multiple sclerosis. Antel, J.P., Bania, M.B., Reder, A., Cashman, N. J. Immunol. (1986) [Pubmed]
  34. Is HIV infection associated with an increase in the prevalence of cervical neoplasia? Smith, J.R., Kitchen, V.S., Botcherby, M., Hepburn, M., Wells, C., Gor, D., Forster, S.M., Harris, J.R., Steer, P., Mason, P. British journal of obstetrics and gynaecology. (1993) [Pubmed]
  35. Mitogenic effects of mycotoxins on T4 lymphocytes. Griffiths, B.B., Rea, W.J., Johnson, A.R., Ross, G.H. Microbios (1996) [Pubmed]
  36. The relationship of HIV-1 viral sequences detected by the polymerase chain reaction in haemophilic patients to clinical and other markers of infection. Dannatt, A.H., Goodwin, S.J., Dasani, H., Bowen, D.J., Peake, I.R., Bloom, A.L. Clinical and laboratory haematology. (1992) [Pubmed]
WikiGenes - Universities