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Disease relevance of Hyperhidrosis


Psychiatry related information on Hyperhidrosis


High impact information on Hyperhidrosis

  • The patients had rates of sweat production greater than 50 mg per minute and had had primary axillary hyperhidrosis that was unresponsive to topical therapy with aluminum chloride for more than one year [8].
  • Clonidine and hyperhidrosis [9].
  • Concentration of plasma noradrenaline was also lower on the painful side in patients with widespread allodynia, and in those with hyperhidrosis in the affected hand or foot [10].
  • METHODS: In a prospective, single blind, randomized trial, 24 patients with severe palmar hyperhidrosis received either a low (50 U) or a high dose (100 U) of botulinum toxin type A (Botox, Allergan) injected intradermally in 20 sites in each palm [11].
  • Increased serum CGRP was correlated to the incidence of nerve lesions (p < 0.02) and hyperhidrosis (p < 0.04) [12].

Chemical compound and disease context of Hyperhidrosis

  • In the patient with hyperhidrosis, a prominent melatonin rhythm was observed preoperatively in the CSF and plasma [13].
  • CONCLUSION: Botulinum toxin is effective in reducing hyperhidrosis disability and limitations in everyday activities when given in association with paroxetine to subjects with SAD [6].
  • However, sympathetic failure, as indicated by impairment of sympathetic vasoconstrictor reflexes (P<0.02) and hyperhidrosis (P<0.01), was found exclusively in CRPS patients [14].
  • Thirteen healthy volunteers, three patients with chronic fungal disease and one patient with palmar-plantar hyperhidrosis were given 400 mg of ketoconazole daily for various lengths of time [15].
  • Mexiletine on segmental hyperhidrosis [16].

Biological context of Hyperhidrosis


Anatomical context of Hyperhidrosis


Gene context of Hyperhidrosis

  • The VIP concentration was unchanged in skin affected by axillary hyperhidrosis [25].
  • The neuropeptides vasoactive intestinal polypeptide (VIP), substance P and somatostatin were studied in skin biopsies from patients with eczema, psoriasis and axillary hyperhidrosis [25].
  • METHODS: A total of 176 procedures (91 patients) were carried out in the ETS 2-4 group and 103 procedures (53 patients) in the ESB 4 group: 60.4 and 43.4% had palmar hyperhidrosis, 8.8 and 5.7% had isolated axillary, and 30.8 and 50.9% had combined manifestations, respectively [26].
  • SUBJECTS: 630 consecutive operations in 352 patients (median age 30.1 yrs) for primary palmar (68%), axillary (12.7%) and combined hyperhidrosis (19.3%) [27].
  • PURPOSE: The purpose of this study was to examine the immediate and mid-term results of thoracoscopic upper dorsal (T2-T3) sympathectomy for primary palmar hyperhidrosis [28].

Analytical, diagnostic and therapeutic context of Hyperhidrosis


  1. Neuroleptic malignant syndrome in a parkinsonian woman during the premenstrual period. Mizuta, E., Yamasaki, S., Nakatake, M., Kuno, S. Neurology (1993) [Pubmed]
  2. Early sequelae of gunshot wounds to the spine: radiologic diagnosis. Gellad, F.E., Paul, K.S., Geisler, F.H. Radiology. (1988) [Pubmed]
  3. Palmar hyperhidrosis--which is the best level of denervation using video-assisted thoracoscopic sympathectomy: T2 or T3 ganglion? Yazbek, G., Wolosker, N., de Campos, J.R., Kauffman, P., Ishy, A., Puech-Leão, P. J. Vasc. Surg. (2005) [Pubmed]
  4. Problems with botulinum toxin treatment in mitochondrial cytopathy: case report and review of the literature. Gioltzoglou, T., Cordivari, C., Lee, P.J., Hanna, M.G., Lees, A.J. J. Neurol. Neurosurg. Psychiatr. (2005) [Pubmed]
  5. Genetic linkage of Meleda disease to chromosome 8qter. Fischer, J., Bouadjar, B., Heilig, R., Fizames, C., Prud'homme, J.F., Weissenbach, J. Eur. J. Hum. Genet. (1998) [Pubmed]
  6. Botulinum toxin treatment of social anxiety disorder with hyperhidrosis: a placebo-controlled double-blind trial. Connor, K.M., Cook, J.L., Davidson, J.R. The Journal of clinical psychiatry. (2006) [Pubmed]
  7. Phacomatosis pigmentokeratotica (Happle) in a 23-year-old man. Wollenberg, A., Butnaru, C., Oppel, T. Acta Derm. Venereol. (2002) [Pubmed]
  8. Botulinum toxin A for axillary hyperhidrosis (excessive sweating). Heckmann, M., Ceballos-Baumann, A.O., Plewig, G. N. Engl. J. Med. (2001) [Pubmed]
  9. Clonidine and hyperhidrosis. Conrad, F., Baumgartner, H., Wiedermann, C., Klein, G. Ann. Intern. Med. (1983) [Pubmed]
  10. Reflex sympathetic dystrophy: the significance of differing plasma catecholamine concentrations in affected and unaffected limbs. Drummond, P.D., Finch, P.M., Smythe, G.A. Brain (1991) [Pubmed]
  11. Botulinum toxin type A in primary palmar hyperhidrosis: randomized, single-blind, two-dose study. Saadia, D., Voustianiouk, A., Wang, A.K., Kaufmann, H. Neurology (2001) [Pubmed]
  12. The important role of neuropeptides in complex regional pain syndrome. Birklein, F., Schmelz, M., Schifter, S., Weber, M. Neurology (2001) [Pubmed]
  13. Sequential cerebrospinal fluid and plasma sampling in humans: 24-hour melatonin measurements in normal subjects and after peripheral sympathectomy. Bruce, J., Tamarkin, L., Riedel, C., Markey, S., Oldfield, E. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  14. Despite clinical similarities there are significant differences between acute limb trauma and complex regional pain syndrome I (CRPS I). Birklein, F., Künzel, W., Sieweke, N. Pain (2001) [Pubmed]
  15. Orally administered ketoconazole: route of delivery to the human stratum corneum. Harris, R., Jones, H.E., Artis, W.M. Antimicrob. Agents Chemother. (1983) [Pubmed]
  16. Mexiletine on segmental hyperhidrosis. Sudo, K., Miyazaki, Y., Tajima, Y., Matsumoto, A., Tashiro, K., Moriwaka, F. J. Neurol. Neurosurg. Psychiatr. (2002) [Pubmed]
  17. The place of botulinum toxin type A in the treatment of focal hyperhidrosis. Lowe, N., Campanati, A., Bodokh, I., Cliff, S., Jaen, P., Kreyden, O., Naumann, M., Offidani, A., Vadoud, J., Hamm, H. Br. J. Dermatol. (2004) [Pubmed]
  18. Nail-patella syndrome associated with respiratory chain disorder. Finsterer, J., Stöllberger, C., Wanschitz, J., Jaksch, M., Budka, H. Eur. Neurol. (2001) [Pubmed]
  19. Effects of endoscopic transthoracic sympathicotomy on hemodynamic and neurohumoral responses to exercise in humans. Nakamura, Y., Fujimoto, M., Nagata, Y., Shiraishi, K., Yoshizawa, H., Kida, H., Matsumoto, Y. Circ. J. (2002) [Pubmed]
  20. Phenoxybenzamine and sweating in the spinal cord injury patient. Shessel, F.S., Carrion, H.M., Politano, V.A. J. Urol. (1978) [Pubmed]
  21. A new mode of percutaneous upper thoracic phenol sympathicolysis: report of 50 cases. Wang, Y.C., Wei, S.H., Sun, M.H., Lin, C.W. Neurosurgery (2001) [Pubmed]
  22. Episodic spontaneous hypothermia with hyperhidrosis: implications for pathogenesis. Sheth, R.D., Barron, T.F., Hartlage, P.L. Pediatric neurology. (1994) [Pubmed]
  23. Sympathetic ganglion blockade for the management of hyperhidrosis. Kobayashi, K., Omote, K., Homma, E., Abe, T., Iitoyo, M. J. Dermatol. (1994) [Pubmed]
  24. Comparison of sympathetic skin response between palmar hyperhidrotic and normal subjects. Kazemi, B., Yahyaii, L., Salmanpour, R., Hadianfard, M.J., Shirzi, Z.R. Electromyography and clinical neurophysiology. (2004) [Pubmed]
  25. Neuropeptides in skin disease: increased VIP in eczema and psoriasis but not axillary hyperhidrosis. Anand, P., Springall, D.R., Blank, M.A., Sellu, D., Polak, J.M., Bloom, S.R. Br. J. Dermatol. (1991) [Pubmed]
  26. Limited endoscopic thoracic sympathetic block for hyperhidrosis of the upper limb: reduction of compensatory sweating by clipping T4. Neumayer, C., Zacherl, J., Holak, G., Függer, R., Jakesz, R., Herbst, F., Bischof, G. Surgical endoscopy. (2004) [Pubmed]
  27. Long-term results of 630 thoracoscopic sympathicotomies for primary hyperhidrosis: the Vienna experience. Zacherl, J., Huber, E.R., Imhof, M., Plas, E.G., Herbst, F., Függer, R. The European journal of surgery. Supplement. : = Acta chirurgica. Supplement. (1998) [Pubmed]
  28. Upper dorsal thoracoscopic sympathectomy for palmar hyperhidrosis: improved intermediate-term results. Kopelman, D., Hashmonai, M., Ehrenreich, M., Bahous, H., Assalia, A. J. Vasc. Surg. (1996) [Pubmed]
  29. A comparison of topical tannic acid versus iontophoresis in the medical treatment of palmar hyperhidrosis. Goh, C.L., Yoyong, K. Singapore medical journal. (1996) [Pubmed]
  30. Thoracoscopic sympathetic surgery for hyperhidrosis. Lee, D.Y., Hong, Y.J., Shin, H.K. Yonsei Med. J. (1999) [Pubmed]
  31. Recalcitrant unilateral infection associated with congenital leg hypertrophy cleared by control of hyperhidrosis. Shelley, W.B., Shelley, E.D. Cutis; cutaneous medicine for the practitioner. (1984) [Pubmed]
  32. Transthoracic video endoscopic electrocautery of sympathetic ganglia for hyperhidrosis palmaris: special reference to localization of the first and second ribs. Wong, C.W. Surgical neurology. (1997) [Pubmed]
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