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Gene Review

RAVER1  -  ribonucleoprotein, PTB-binding 1

Homo sapiens

Synonyms: KIAA1978, Protein raver-1, Ribonucleoprotein PTB-binding 1
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High impact information on RAVER1

  • By screening a yeast two-hybrid library with COOH-terminal fragments of vinculin/metavinculin as the bait, we identified a new protein termed raver1 [1].
  • Hence, raver1 is a dual compartment protein, which is consistent with the presence of nuclear location signal and nuclear export sequence motifs in its sequence [1].
  • The NH2-terminal part of raver1 contains three RNA recognition motifs with homology to members of the heterogeneous nuclear RNP (hnRNP) family [1].
  • We propose that raver1 may coordinate RNA processing and targeting as required for microfilament anchoring in specific adhesion sites [1].
  • Raver1 is an 80-kD multidomain protein and widely expressed but to varying amounts in different cell lines [1].

Biological context of RAVER1

  • In contrast to ubiquitously expressed raver1, raver2 exerts a distinct spatio-temporal expression pattern during embryogenesis and is essentially restricted to brain, lung, and kidney in the adult mouse [2].
  • Raver2 was identified as a novel member of the hnRNP family based on sequence homology within three RNA recognition motifs and its general domain organization reminiscent of the previously described raver1 protein [2].

Other interactions of RAVER1

  • Like raver1, raver2 contains two putative nuclear localization signals and a potential nuclear export sequence, and also displays nucleo-cytoplasmic shuttling in a heterokaryon assay [2].


  1. Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins. Hüttelmaier, S., Illenberger, S., Grosheva, I., Rüdiger, M., Singer, R.H., Jockusch, B.M. J. Cell Biol. (2001) [Pubmed]
  2. Raver2, a new member of the hnRNP family. Kleinhenz, B., Fabienke, M., Swiniarski, S., Wittenmayer, N., Kirsch, J., Jockusch, B.M., Arnold, H.H., Illenberger, S. FEBS Lett. (2005) [Pubmed]
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