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Gene Review:

hol - holin

Lactobacillus phage phiadh

Henrich, B. et al., Bon, J. et al., Garcia, M. et al., Oki, M. et al.

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Disease relevance of hol

ORF4 encodes a 77-amino-acid holin-like protein with significant similarity to the holin of Lactococcus lactis r1t bacteriophage [1].
Both genes showed 100% sequence homology to that of the peptidoglycan hydrolase and holin genes of the S. aureus phage phi 11 reported earlier [2].

High impact information on hol

Nucleotide sequencing of a 3813-bp phi g1e DNA revealed five successive open reading frames (ORF), Rorf50, Rorf118, hol, and lys and Rorf175, in the same DNA strand [3].

Biological context of hol

Nucleotide sequencing of a 1,735-bp DNA fragment revealed two adjacent coding regions of 342 bp (hol) and 951 bp (lys) in the same reading frame which appear to belong to a common transcriptional unit [4].

Other interactions of hol

Proteins corresponding to the predicted gene products, holin (12.9 kDa) and lysin (34.7 kDa), were identified by in vitro and in vivo expression of the cloned genes [4].

References

Expression of Mycobacteriophage Ms6 lysis genes is driven by two sigma(70)-like promoters and is dependent on a transcription termination signal present in the leader RNA. Garcia, M., Pimentel, M., Moniz-Pereira, J. J. Bacteriol. (2002) [Pubmed]
Molecular analysis of lytic genes of bacteriophage 80 alpha of Staphylococcus aureus. Bon, J., Mani, N., Jayaswal, R.K. Can. J. Microbiol. (1997) [Pubmed]
Cloning, sequence analysis, and expression of the genes encoding lytic functions of Bacteriophage phi g1e. Oki, M., Kakikawa, M., Yamada, K., Taketo, A., Kodaira, K.I. Gene (1996) [Pubmed]
Primary structure and functional analysis of the lysis genes of Lactobacillus gasseri bacteriophage phi adh. Henrich, B., Binishofer, B., Bläsi, U. J. Bacteriol. (1995) [Pubmed]

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