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Gene Review

Slc29a2  -  solute carrier family 29 (nucleoside...

Mus musculus

Synonyms: 36 kDa hydrophobic nucleolar protein, 36 kDa nucleolar protein HNP36, Delayed-early response protein 12, Der12, ENT2, ...
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High impact information on Slc29a2

  • Macrophages express at least the concentrative systems N1 and N2 (CNT2 and CNT1 genes, respectively) and the equilibrative systems es and ei (ENT1 and ENT2 genes, respectively) [1].

Biological context of Slc29a2


Associations of Slc29a2 with chemical compounds

  • Mammalian cells express at least two subtypes of equilibrative nucleoside transporters, i.e. ENT1 and ENT2, which can be distinguished functionally by their sensitivity and resistance respectively to inhibition by nitrobenzylthioinosine [3].

Other interactions of Slc29a2

  • Reverse transcription-polymerase chain reaction identified the two equilibrative nucleoside transporters, ENT1 and ENT2, together with the concentrative nucleoside transporter CNT2, whereas CNT3 was absent, and CNT1 expression could not be investigated [4].


  1. Macrophages require different nucleoside transport systems for proliferation and activation. Soler, C., García-Manteiga, J., Valdés, R., Xaus, J., Comalada, M., Casado, F.J., Pastor-Anglada, M., Celada, A., Felipe, A. FASEB J. (2001) [Pubmed]
  2. Nucleoside transport at the blood-testis barrier studied with primary-cultured sertoli cells. Kato, R., Maeda, T., Akaike, T., Tamai, I. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  3. Molecular cloning and functional characterization of inhibitor-sensitive (mENT1) and inhibitor-resistant (mENT2) equilibrative nucleoside transporters from mouse brain. Kiss, A., Farah, K., Kim, J., Garriock, R.J., Drysdale, T.A., Hammond, J.R. Biochem. J. (2000) [Pubmed]
  4. Nucleoside transporter expression and function in cultured mouse astrocytes. Peng, L., Huang, R., Yu, A.C., Fung, K.Y., Rathbone, M.P., Hertz, L. Glia (2005) [Pubmed]
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