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Gene Review

Slc29a1  -  solute carrier family 29 (nucleoside...

Mus musculus

Synonyms: 1200014D21Rik, AA407560, ENT1, Ent1, Equilibrative NBMPR-sensitive nucleoside transporter, ...
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Disease relevance of Slc29a1

  • Therefore, we investigated the effects of chronic hypoxia on ENT1, the predominant ENT isoform in cardiomyocytes [1].

Psychiatry related information on Slc29a1


High impact information on Slc29a1


Biological context of Slc29a1


Anatomical context of Slc29a1


Associations of Slc29a1 with chemical compounds

  • Mammalian cells express at least two subtypes of equilibrative nucleoside transporters, i.e. ENT1 and ENT2, which can be distinguished functionally by their sensitivity and resistance respectively to inhibition by nitrobenzylthioinosine [6].
  • The ENT1 transporters exhibit distinctive species differences in their sensitivities to inhibition by dipyridamole, dilazep and draflazine (human>mouse>rat) [6].

Other interactions of Slc29a1

  • Reverse transcription-polymerase chain reaction identified the two equilibrative nucleoside transporters, ENT1 and ENT2, together with the concentrative nucleoside transporter CNT2, whereas CNT3 was absent, and CNT1 expression could not be investigated [12].


  1. Hypoxia regulates the adenosine transporter, mENT1, in the murine cardiomyocyte cell line, HL-1. Chaudary, N., Naydenova, Z., Shuralyova, I., Coe, I.R. Cardiovasc. Res. (2004) [Pubmed]
  2. The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference. Choi, D.S., Cascini, M.G., Mailliard, W., Young, H., Paredes, P., McMahon, T., Diamond, I., Bonci, A., Messing, R.O. Nat. Neurosci. (2004) [Pubmed]
  3. Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. Carrier, E.J., Auchampach, J.A., Hillard, C.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. Redistribution of nucleoside transporters to the cell membrane provides a novel approach for imaging thymidylate synthase inhibition by positron emission tomography. Perumal, M., Pillai, R.G., Barthel, H., Leyton, J., Latigo, J.R., Forster, M., Mitchell, F., Jackman, A.L., Aboagye, E.O. Cancer Res. (2006) [Pubmed]
  5. Molecular evolution of the equilibrative nucleoside transporter family: identification of novel family members in prokaryotes and eukaryotes. Acimovic, Y., Coe, I.R. Mol. Biol. Evol. (2002) [Pubmed]
  6. Molecular cloning and functional characterization of inhibitor-sensitive (mENT1) and inhibitor-resistant (mENT2) equilibrative nucleoside transporters from mouse brain. Kiss, A., Farah, K., Kim, J., Garriock, R.J., Drysdale, T.A., Hammond, J.R. Biochem. J. (2000) [Pubmed]
  7. Cloning of a novel isoform of the mouse NBMPR-sensitive equilibrative nucleoside transporter (ENT1) lacking a putative phosphorylation site. Handa, M., Choi, D.S., Caldeiro, R.M., Messing, R.O., Gordon, A.S., Diamond, I. Gene (2001) [Pubmed]
  8. Nucleoside transport at the blood-testis barrier studied with primary-cultured sertoli cells. Kato, R., Maeda, T., Akaike, T., Tamai, I. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  9. Genomic organization and expression of the mouse equilibrative, nitrobenzylthioinosine-sensitive nucleoside transporter 1 (ENT1) gene. Choi, D.S., Handa, M., Young, H., Gordon, A.S., Diamond, I., Messing, R.O. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  10. Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH. Barnes, K., Dobrzynski, H., Foppolo, S., Beal, P.R., Ismat, F., Scullion, E.R., Sun, L., Tellez, J., Ritzel, M.W., Claycomb, W.C., Cass, C.E., Young, J.D., Billeter-Clark, R., Boyett, M.R., Baldwin, S.A. Circ. Res. (2006) [Pubmed]
  11. Interferon-gamma regulates nucleoside transport systems in macrophages through signal transduction and activator of transduction factor 1 (STAT1)-dependent and -independent signalling pathways. Soler, C., Felipe, A., García-Manteiga, J., Serra, M., Guillén-Gómez, E., Casado, F.J., MacLeod, C., Modolell, M., Pastor-Anglada, M., Celada, A. Biochem. J. (2003) [Pubmed]
  12. Nucleoside transporter expression and function in cultured mouse astrocytes. Peng, L., Huang, R., Yu, A.C., Fung, K.Y., Rathbone, M.P., Hertz, L. Glia (2005) [Pubmed]
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