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Gene Review:

Dsg2 - desmoglein 2

Mus musculus

Synonyms: AA408168, D18Ertd293e, Desmoglein-2

Eshkind, L. et al., Ota, T. et al., Mahoney, M.G. et al.

Ota, Amagai, Watanabe, Nishikawa, Mahoney, Simpson, Aho, Uitto, Pulkkinen,

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Disease relevance of Dsg2

CONCLUSION: These findings indicate that IgG autoantibodies against Dsg2 are not involved in PNP, CD or UC and suggest the existence of other unknown cell surface target antigen(s) in bronchiolitis obliterans in PNP [1].

High impact information on Dsg2

We present evidence that Dsg2, which is located in desmoplakin-negative wild-type ES cells in non-desmosomal junctions, is needed for normal ES cell proliferation [2].
Desmoglein 2 (Dsg2) is a Ca(2+)-dependent adhesion molecule of desmosomes and is synthesized in all desmosome-bearing tissues from their earliest appearance onward [2].
In this study, we have cloned and characterized the mouse Dsg1 and Dsg2 genes [3].
Loss of desmoglein 2 suggests essential functions for early embryonic development and proliferation of embryonal stem cells [2].

References

No involvement of IgG autoantibodies against extracellular domains of desmoglein 2 in paraneoplastic pemphigus or inflammatory bowel diseases. Ota, T., Amagai, M., Watanabe, M., Nishikawa, T. J. Dermatol. Sci. (2003) [Pubmed]
Loss of desmoglein 2 suggests essential functions for early embryonic development and proliferation of embryonal stem cells. Eshkind, L., Tian, Q., Schmidt, A., Franke, W.W., Windoffer, R., Leube, R.E. Eur. J. Cell Biol. (2002) [Pubmed]
Interspecies conservation and differential expression of mouse desmoglein gene family. Mahoney, M.G., Simpson, A., Aho, S., Uitto, J., Pulkkinen, L. Exp. Dermatol. (2002) [Pubmed]

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DSG2	Bos taurus
DSG2	Canis lupus familiaris
si:ch73-74h11.1	Danio rerio
dsg2l	Danio rerio
LOC101882022	Danio rerio
dsg2.1	Danio rerio
DSG2	Gallus gallus
DSG2	Homo sapiens
DSG2	Macaca mulatta
DSG2	Pan troglodytes
Dsg2	Rattus norvegicus
dsg2	Xenopus (Silurana) tropicalis

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