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Gene Review

ADAMTS14  -  ADAM metallopeptidase with thrombospondin...

Homo sapiens

Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 14, ADAM-TS 14, ADAM-TS14, ADAMTS-14
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Disease relevance of ADAMTS14


High impact information on ADAMTS14

  • Although Adamts14 lacked developmental tissue-specific expression, it was co-expressed with Adamts2 in mature dermis, which possibly explains the presence of some processed skin procollagen in dermatosparaxis [2].
  • The tissue distribution of ADAMTS-14, the regulation of the gene expression by various cytokines and the activity of the recombinant enzyme are evaluated [3].
  • These findings suggest a potentially important role for the ADAMTS14 gene in predisposition to MS [1].
  • We cloned and characterized a novel human ADAMTS gene, ADAMTS14, which is located on human chromosome 10q2 [4].

Analytical, diagnostic and therapeutic context of ADAMTS14

  • By RT-PCR analysis we demonstrated that ADAMTS14 is expressed in human retina and also at low levels in adult brain, lung and placenta [4].


  1. Genetic association between polymorphisms in the ADAMTS14 gene and multiple sclerosis. Goertsches, R., Comabella, M., Navarro, A., Perkal, H., Montalban, X. J. Neuroimmunol. (2005) [Pubmed]
  2. Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis. Le Goff, C., Somerville, R.P., Kesteloot, F., Powell, K., Birk, D.E., Colige, A.C., Apte, S.S. Development (2006) [Pubmed]
  3. Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3. Colige, A., Vandenberghe, I., Thiry, M., Lambert, C.A., Van Beeumen, J., Li, S.W., Prockop, D.J., Lapiere, C.M., Nusgens, B.V. J. Biol. Chem. (2002) [Pubmed]
  4. Characterization of ADAMTS14, a novel member of the ADAMTS metalloproteinase family. Bolz, H., Ramírez, A., von Brederlow, B., Kubisch, C. Biochim. Biophys. Acta (2001) [Pubmed]
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