Gene Review:
orc7 - orc / cell division control protein 6
Halobacterium sp. NRC-1
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High impact information on orc7
- Our results indicate that, in halophilic archaea, a chromosomal origin of replication is physically linked to orc7 homologs and that this element is sufficient to promote autonomous replication [1].
- Deletion analysis showed that sequences located up to 750 bp upstream of the orc7 gene translational start, plus the orc7 gene and 50 bp downstream, are sufficient to endow the plasmid with replication ability, as judged by expression of a plasmid-encoded mevinolin resistance selectable marker and plasmid recovery after transformation [1].
References
- An archaeal chromosomal autonomously replicating sequence element from an extreme halophile, Halobacterium sp. strain NRC-1. Berquist, B.R., DasSarma, S. J. Bacteriol. (2003) [Pubmed]
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