Chemical Compound Review:
Mevacor [(1S,3R,7R,8S,8aS)-8-[2- [(2R,4R)-4-hydroxy...
Synonyms:
mevinolin, lovastatin, Monacolin K, MK-803, MK803, ...
- Transformation of Halobacterium halobium: development of vectors and investigation of gas vesicle synthesis. Blaseio, U., Pfeifer, F. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Pharmacologic treatment of hyperlipidemia reduces glomerular injury in rat 5/6 nephrectomy model of chronic renal failure. Kasiske, B.L., O'Donnell, M.P., Garvis, W.J., Keane, W.F. Circ. Res. (1988)
- Abolition of mevinolin-induced growth inhibition in human fibroblasts following transformation by simian virus 40. Larsson, O., Barrios, C., Latham, C., Ruiz, J., Zetterberg, A., Zickert, P., Wejde, J. Cancer Res. (1989)
- Combined antihypertensive and lipid-lowering therapy in experimental glomerulonephritis. Rubin, R., Silbiger, S., Sablay, L., Neugarten, J. Hypertension (1994)
- Differentiation of neuroblastoma cells induced by an inhibitor of mevalonate synthesis: relation of neurite outgrowth and acetylcholinesterase activity to changes in cell proliferation and blocked isoprenoid synthesis. Maltese, W.A., Sheridan, K.M. J. Cell. Physiol. (1985)
- Effects of exercise and lovastatin on serum creatine kinase activity. Thompson, P.D., Gadaleta, P.A., Yurgalevitch, S., Cullinane, E., Herbert, P.N. Metab. Clin. Exp. (1991)
- Platelet-mediated cholesterol accumulation in cultured aortic smooth muscle cells. Kruth, H.S. Science (1985)
- Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Maltese, W.A., Defendini, R., Green, R.A., Sheridan, K.M., Donley, D.K. J. Clin. Invest. (1985)
- Regulation of plasma levels of low-density lipoprotein cholesterol: interpretation of data on low-density lipoprotein turnover in man. Meddings, J.B., Dietschy, J.M. Circulation (1986)
- Role of mevalonate in regulation of cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A reductase in cultured cells and their cytoplasts. Popják, G., Clarke, C.F., Hadley, C., Meenan, A. J. Lipid Res. (1985)
- The effects of mevinolin and neomycin alone and in combination on plasma lipid and lipoprotein concentrations in type II hyperlipoproteinemia. Hoeg, J.M., Maher, M.B., Bailey, K.R., Brewer, H.B. Atherosclerosis (1986)
- Effects of monoterpenes and mevinolin on murine colon tumor CT-26 in vitro and its hepatic "metastases" in vivo. Broitman, S.A., Wilkinson, J., Cerda, S., Branch, S.K. Adv. Exp. Med. Biol. (1996)
- Influence of combined therapy with mevinolin and interruption of bile-acid reabsorption on low density lipoproteins in heterozygous familial hypercholesterolemia. Grundy, S.M., Vega, G.L., Bilheimer, D.W. Ann. Intern. Med. (1985)
- Shuttle vectors for the archaebacterium Halobacterium volcanii. Lam, W.L., Doolittle, W.F. Proc. Natl. Acad. Sci. U.S.A. (1989)
- Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes. Bilheimer, D.W., Grundy, S.M., Brown, M.S., Goldstein, J.L. Proc. Natl. Acad. Sci. U.S.A. (1983)
- Mevinolin, an inhibitor of cholesterol biosynthesis, drastically depresses Ca2+ channel activity and uncouples excitation from contraction in cardiac cells in culture. Renaud, J.F., Schmid, A., Romey, G., Nano, J.L., Lazdunski, M. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Isoprenylation is required for the processing of the lamin A precursor. Beck, L.A., Hosick, T.J., Sinensky, M. J. Cell Biol. (1990)
- Hydroxymethylglutaryl-coenzyme A reductase-containing hepatocytes are distributed periportally in normal and mevinolin-treated rat livers. Singer, I.I., Kawka, D.W., Kazazis, D.M., Alberts, A.W., Chen, J.S., Huff, J.W., Ness, G.C. Proc. Natl. Acad. Sci. U.S.A. (1984)
- Modulation of human lymphocyte responses by low density lipoproteins (LDL): enhancement but not immunosuppression is mediated by LDL receptors. Cuthbert, J.A., Lipsky, P.E. Proc. Natl. Acad. Sci. U.S.A. (1984)
- The influence of mevinolin on the adrenal cortical response to corticotropin in heterozygous familial hypercholesterolemia. Illingworth, D.R., Corbin, D. Proc. Natl. Acad. Sci. U.S.A. (1985)
- Testis-specific transcription initiation sites of rat farnesyl pyrophosphate synthetase mRNA. Teruya, J.H., Kutsunai, S.Y., Spear, D.H., Edwards, P.A., Clarke, C.F. Mol. Cell. Biol. (1990)
- Normal cholesterol levels with lovastatin (mevinolin) therapy in a child with homozygous familial hypercholesterolemia following liver transplantation. East, C., Grundy, S.M., Bilheimer, D.W. JAMA (1986)
- Plasma mevalonate as a measure of cholesterol synthesis in man. Parker, T.S., McNamara, D.J., Brown, C.D., Kolb, R., Ahrens, E.H., Alberts, A.W., Tobert, J., Chen, J., De Schepper, P.J. J. Clin. Invest. (1984)
- Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development. Rodríguez-Concepción, M., Forés, O., Martinez-García, J.F., González, V., Phillips, M.A., Ferrer, A., Boronat, A. Plant Cell (2004)
- Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cells. Libertini, S., Iacuzzo, I., Ferraro, A., Vitale, M., Bifulco, M., Fusco, A., Portella, G. Endocrinology (2007)
- Activation of the integrated stress response regulates lovastatin-induced apoptosis. Niknejad, N., Morley, M., Dimitroulakos, J. J. Biol. Chem. (2007)
- Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways. Campbell, M., Allen, W.E., Sawyer, C., Vanhaesebroeck, B., Trimble, E.R. Circ. Res. (2004)
- Transcriptional derepression of the murine Cyp1a-1 gene by mevinolin. Puga, A., Raychaudhuri, B., Nebert, D.W. FASEB J. (1992)
- Regulation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A synthase and the chromosomal localization of the human gene. Mehrabian, M., Callaway, K.A., Clarke, C.F., Tanaka, R.D., Greenspan, M., Lusis, A.J., Sparkes, R.S., Mohandas, T., Edmond, J., Fogelman, A.M. J. Biol. Chem. (1986)
- Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase. Inglese, J., Glickman, J.F., Lorenz, W., Caron, M.G., Lefkowitz, R.J. J. Biol. Chem. (1992)
- Relation of mevalonate synthesis to mitochondrial ubiquinone content and respiratory function in cultured neuroblastoma cells. Maltese, W.A., Aprille, J.R. J. Biol. Chem. (1985)
- Effects of mevinolin on cell cycle progression and viability of tobacco BY-2 cells. Hemmerlin, A., Bach, T.J. Plant J. (1998)