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Gene Review:

NS1 - nonstructural protein 1

Influenza A virus (A/Hong Kong/1073/99(H9N2))

Wang, S. et al., Zhao, S. et al.

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Disease relevance of NS1

Genetic analysis indicated that three lineages of H9N2 viruses have been established in Eurasia and only one lineage is present on chicken farms in mainland China. Here, NS1 genes of eight H9N2 chicken influenza viruses, isolated in mainland China during 1998-2002, were completely sequenced and phylogenetically analyzed [1].
Genetic analysis of the nonstructural (NS) genes of H9N2 chicken influenza viruses isolated in China during 1998-2002 [1].
Detection of antibodies to the nonstructural protein (NS1) of avian influenza viruses allows distinction between vaccinated and infected chickens [2].

High impact information on NS1

Except for the amino acid at position 225, the additional amino acid sequence (13 AAs) of NS1 of Ck/NM/Zh/02 at the carboxy-terminus is identical with that of Ck/Kor/323/96 [1].

References

Genetic analysis of the nonstructural (NS) genes of H9N2 chicken influenza viruses isolated in China during 1998-2002. Wang, S., Shi, W.M., Mweene, A., Wei, H.L., Bai, G.R., Liu, J.H. Virus Genes (2005) [Pubmed]
Detection of antibodies to the nonstructural protein (NS1) of avian influenza viruses allows distinction between vaccinated and infected chickens. Zhao, S., Jin, M., Li, H., Tan, Y., Wang, G., Zhang, R., Chen, H. Avian Dis. (2005) [Pubmed]

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