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MeSH Review:

Influenza A Virus, H9N2 Subtype

Leneva, I.A. et al., Leneva, I.A. et al., Lin, Y.P. et al., Ninomiya, A. et al., Liu, J.H. et al.

Lin, Shaw, Gregory, Cameron, Lim, Klimov, Subbarao, Guan, Krauss, Shortridge, Webster, Cox, Hay,

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Disease relevance of Influenza A Virus, H9N2 Subtype

At a dose of 10 mg/kg, zanamivir completely protected mice from infection with H9N2 viruses and increased the mean survival day and the number of survivors infected with H6N1 and H5N1 viruses [1].

High impact information on Influenza A Virus, H9N2 Subtype

Although differing in their surface hemagglutinin and neuraminidase components, a notable feature of these H9N2 viruses is that the six genes encoding the internal components of the virus are similar to those of the 1997 H5N1 human and avian isolates [2].
Additionally, A/Chicken/HK/G9/97 (H9N2) virus has PB1 and PB2 genes that are highly related to those of A/HK/156/97 (H5N1), A/Teal/HK/W312/97 (H6N1), and A/Quail/HK/G1/97 (H9N2) viruses [1].
Phylogenetic analysis of hemagglutinin and neuraminidase genes of H9N2 viruses isolated from migratory ducks [3].
Antibodies to H9 virus, on the other hand, were found only in the sera collected in 1998, not in those collected in 1977-1982, correlating with the recent spread in poultry and subsequent isolation of H9N2 viruses from pigs and humans in 1998 [4].
Here we demonstrate the efficacy of the neuraminidase inhibitor GS4104 (oseltamivir phosphate) against these H5N1 and H9N2 viruses [5].

Chemical compound and disease context of Influenza A Virus, H9N2 Subtype

Oral administration of GS4104 (0.1 mg/kg per day) in combination with rimantadine (1 mg/kg per day) reduced the number of deaths of mice infected with 100 MLD(50) of H9N2 virus and prevented the deaths of mice infected with 5 MLD(50) of virus [5].

References

Efficacy of zanamivir against avian influenza A viruses that possess genes encoding H5N1 internal proteins and are pathogenic in mammals. Leneva, I.A., Goloubeva, O., Fenton, R.J., Tisdale, M., Webster, R.G. Antimicrob. Agents Chemother. (2001) [Pubmed]
Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates. Lin, Y.P., Shaw, M., Gregory, V., Cameron, K., Lim, W., Klimov, A., Subbarao, K., Guan, Y., Krauss, S., Shortridge, K., Webster, R., Cox, N., Hay, A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
Phylogenetic analysis of hemagglutinin and neuraminidase genes of H9N2 viruses isolated from migratory ducks. Liu, J.H., Okazaki, K., Shi, W.M., Kida, H. Virus Genes (2003) [Pubmed]
Seroepidemiological evidence of avian H4, H5, and H9 influenza A virus transmission to pigs in southeastern China. Ninomiya, A., Takada, A., Okazaki, K., Shortridge, K.F., Kida, H. Vet. Microbiol. (2002) [Pubmed]
The neuraminidase inhibitor GS4104 (oseltamivir phosphate) is efficacious against A/Hong Kong/156/97 (H5N1) and A/Hong Kong/1074/99 (H9N2) influenza viruses. Leneva, I.A., Roberts, N., Govorkova, E.A., Goloubeva, O.G., Webster, R.G. Antiviral Res. (2000) [Pubmed]

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