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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of China


High impact information on China

  • Mitochondrial DNA (mtDNA) sequences that include (a) a part of the cytochrome b gene, (b) two tRNA genes, and (c) a part of the noncoding D-loop region of 31 Anguilla japonica (Japanese eel) and 1 A. marmorata collected from Taiwan, Japan, and mainland China were determined to evaluate the population structure of Japanese eel [6].
  • Trends in human dioxin levels in the region cannot yet be determined, and rigorous controls are needed to reduce emissions of dioxins and human exposure in mainland China [7].
  • Use of an improved method for analysis of urinary aflatoxin M1 in a survey of mainland China and Taiwan [8].
  • Current age- and sex-specific values of blood cholesterol low density lipoprotein cholesterol (LDL-C) and triglyceride (TG) are, in general, higher than values in mainland China, but lower than those in the NHANES III and PROCAM studies [9].
  • Among 198 Mongols from Inner Mongolia, there were 174 lactose malabsorbers (87.9%) [10].

Chemical compound and disease context of China

  • The molecular findings did not suggest an epidemiological link between HIV infection in Hong Kong and Mainland China. Hong Kong's longstanding and extensive methadone treatment network may have contributed to the phenomenon [11].

Biological context of China

  • CONCLUSION: The distribution of vacA, cagA and iceA alleles in H. pylori strains in Hong Kong is similar to that in east Asia. There is a difference in the distribution of genotypes between strains in Hong Kong and those in mainland China, although strains in the two regions exhibit a very close relation [12].
  • Allele frequencies for nine STRs included in the APMF1STR kit were obtained from blood samples of 100 unrelated individuals born in Sinkiang Uygur Autonomy Region of China (NW China) [13].
  • The allelic distribution of nine short tandem repeats (STRs) loci (vWA, FGA, PentaE, D3S1358, D13S317, D5S818, D6S1043, D2S1772 and D7S3048) was examined in 286 Ximeng-Mongolian and 293 Wumeng-Mongolian unrelated individuals living in the Inner Mongolia province, PR China [14].
  • The purpose of this pilot study was to assess DNA damage in buccal cells from individuals chronically exposed to arsenic via drinking water in Ba Men, Inner Mongolia [15].

Associations of China with chemical compounds


Gene context of China

  • This is the first report of geographic cluster of families with SCA6 subtype in Mainland China [21].
  • Spinocerebellar ataxia type 6 in Mainland China: molecular and clinical features in four families [21].
  • To our knowledge, this is the first report of ATM mutations in Mainland China, in which the transversions 1346G>C (Gly449Ala) and 610G>T (Gly204Stop) are two novel, disease-causing mutations [22].
  • These data largely rule out the possibility that a single ancestor bearing an insertion-chromosome immigrated to Japan from Korea or Mainland China and appear to confirm that FCMD carriers are rare outside of Japan [23].
  • SARS is the first major new infectious disease in the 21st century (Rodier, 2003) and is described as a "serious disaster" in mainland China where it caused unprecedented panic and social and economic consequences [24].


  1. Integrated state of subgenomic fragments of hepatitis B virus DNA in hepatocellular carcinoma from mainland China. Zhou, Y.Z., Butel, J.S., Li, P.J., Finegold, M.J., Melnick, J.L. J. Natl. Cancer Inst. (1987) [Pubmed]
  2. HIV/AIDS behavioral surveillance surveys of the cross-border sex-networker population in Hong Kong from 1997 to 2001. Lau, J.T., Tsui, H.Y. Sexually transmitted diseases. (2003) [Pubmed]
  3. Evaluation of clinical and serological data from Taenia solium cysticercosis patients in eastern Inner Mongolia Autonomous Region, China. Ikejima, T., Piao, Z.X., Sako, Y., Sato, M.O., Bao, S., Si, R., Yu, F., Zhang, C.L., Nakao, M., Yamasaki, H., Nakaya, K., Kanazawa, T., Ito, A. Trans. R. Soc. Trop. Med. Hyg. (2005) [Pubmed]
  4. Genetic analysis of the nonstructural (NS) genes of H9N2 chicken influenza viruses isolated in China during 1998-2002. Wang, S., Shi, W.M., Mweene, A., Wei, H.L., Bai, G.R., Liu, J.H. Virus Genes (2005) [Pubmed]
  5. Predicting pressure ulcer risk with the modified Braden, Braden, and Norton scales in acute care hospitals in Mainland China. Kwong, E., Pang, S., Wong, T., Ho, J., Shao-ling, X., Li-jun, T. Applied nursing research : ANR. (2005) [Pubmed]
  6. Population structure of the Japanese eel, Anguilla japonica. Sang, T.K., Chang, H.Y., Chen, C.T., Hui, C.F. Mol. Biol. Evol. (1994) [Pubmed]
  7. Breast milk dioxins in Hong Kong and Pearl River Delta. Hedley, A.J., Wong, T.W., Hui, L.L., Malisch, R., Nelson, E.A. Environ. Health Perspect. (2006) [Pubmed]
  8. Use of an improved method for analysis of urinary aflatoxin M1 in a survey of mainland China and Taiwan. Cheng, Z., Root, M., Pan, W., Chen, J., Campbell, T.C. Cancer Epidemiol. Biomarkers Prev. (1997) [Pubmed]
  9. Plasma lipid profiles and epidemiology of atherosclerotic diseases in Taiwan--a unique experience. Pan, W.H., Chiang, B.N. Atherosclerosis (1995) [Pubmed]
  10. Prevalence of primary adult lactose malabsorption in three populations of northern China. Wang, Y.G., Yan, Y.S., Xu, J.J., Du, R.F., Flatz, S.D., Kühnau, W., Flatz, G. Hum. Genet. (1984) [Pubmed]
  11. The lack of epidemiological link between the HIV type 1 infections in Hong Kong and Mainland China. Lim, W.L., Xing, H., Wong, K.H., Wong, M.C., Shao, Y.M., Ng, M.H., Lee, S.S. AIDS Res. Hum. Retroviruses (2004) [Pubmed]
  12. Distribution of distinct vacA, cagA and iceA alleles in Helicobacter pylori in Hong Kong. Wong, B.C., Yin, Y., Berg, D.E., Xia, H.H., Zhang, J.Z., Wang, W.H., Wong, W.M., Huang, X.R., Tang, V.S., Lam, S.K. Helicobacter (2001) [Pubmed]
  13. STR data for the AmpFLSTR Profiler loci from Sinkiang (NW China). Wang, X., Gao, S., Lai, J., Li, S. Forensic Sci. Int. (2002) [Pubmed]
  14. Population studies on two native Mongolian population groups in China using STR loci. Su, X., Li, D., Lifu, S.L., Yun, P.W., Yun, S. Forensic Sci. Int. (2004) [Pubmed]
  15. DNA damage in buccal epithelial cells from individuals chronically exposed to arsenic via drinking water in Inner Mongolia, China. Feng, Z., Xia, Y., Tian, D., Wu, K., Schmitt, M., Kwok, R.K., Mumford, J.L. Anticancer Res. (2001) [Pubmed]
  16. A serological survey on neutralizing antibody titer of SARS convalescent sera. Zhang, J.S., Chen, J.T., Liu, Y.X., Zhang, Z.S., Gao, H., Liu, Y., Wang, X., Ning, Y., Liu, Y.F., Gao, Q., Xu, J.G., Qin, C., Dong, X.P., Yin, W.D. J. Med. Virol. (2005) [Pubmed]
  17. Prevalence of extended spectrum beta-lactamase (ESBL)-producing clinical isolates in the Asia-Pacific region and South Africa: regional results from SENTRY Antimicrobial Surveillance Program (1998-99). Bell, J.M., Turnidge, J.D., Gales, A.C., Pfaller, M.A., Jones, R.N. Diagn. Microbiol. Infect. Dis. (2002) [Pubmed]
  18. A population-based epidemiological study on cardiovascular risk factors in Kin-Chen, Kinmen. Chen, C.H., Chuang, J.H., Kuo, H.S., Chang, M.S., Wang, S.P., Chou, P. International journal of cardiology. (1995) [Pubmed]
  19. Chronic arsenic exposure and urinary 8-hydroxy-2'-deoxyguanosine in an arsenic-affected area in Inner Mongolia, China. Fujino, Y., Guo, X., Liu, J., Matthews, I.P., Shirane, K., Wu, K., Kasai, H., Miyatake, M., Tanabe, K., Kusuda, T., Yoshimura, T. Journal of exposure analysis and environmental epidemiology. (2005) [Pubmed]
  20. A model for peak and width of signaling windows: Ips duplicatus and Chilo partellus pheromone component proportions--does response have a wider window than production? Schlyter, F., Svensson, M., Zhang, Q.H., Knízek, M., Krokene, P., Ivarsson, P., Birgersson, G. J. Chem. Ecol. (2001) [Pubmed]
  21. Spinocerebellar ataxia type 6 in Mainland China: molecular and clinical features in four families. Jiang, H., Tang, B., Xia, K., Zhou, Y., Xu, B., Zhao, G., Li, H., Shen, L., Pan, Q., Cai, F. J. Neurol. Sci. (2005) [Pubmed]
  22. Mutation analysis of the ATM gene in two Chinese patients with ataxia telangiectasia. Jiang, H., Tang, B., Xia, K., Hu, Z., Shen, L., Tang, J., Zhao, G., Zhang, Y., Cai, F., Pan, Q., Long, Z., Wang, G., Dai, H. J. Neurol. Sci. (2006) [Pubmed]
  23. Founder SVA retrotransposal insertion in Fukuyama-type congenital muscular dystrophy and its origin in Japanese and Northeast Asian populations. Watanabe, M., Kobayashi, K., Jin, F., Park, K.S., Yamada, T., Tokunaga, K., Toda, T. Am. J. Med. Genet. A (2005) [Pubmed]
  24. The battle against SARS: a Chinese story. Liu, C. Australian health review : a publication of the Australian Hospital Association. (2003) [Pubmed]
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