Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Gnmt - glycine N-methyltransferase

Mus musculus

Synonyms: Glycine N-methyltransferase, glycine N methyl transferase

Uthus, E.O. et al., Foussat, J. et al., Chu, R. et al., Aida, K. et al.

Uthus, Brown-Borg, Chu, Lim, Brumfield, Liu, Herring, Ulintz, Reddy, Davison,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Gnmt

In addition, glycine N-methyltransferase, pyrophosphate phosphohydrolase, and protein phosphatase 1D were down-regulated with PPARalpha activation [1].
The specific activity of liver methionine adenosyltransferase (MAT) was significantly elevated (205%, p<0.0001) in the dwarf mice, as were cystathionine synthase (50%, p<0.01), cystathionase (83%, p<0.001), and glycine N-methyltransferase (GNMT, 91%, p<0.001) activities [2].
These results indicate that the sex difference of the mouse GNMT expression is regulated by GH secretion patterns [3].

Analytical, diagnostic and therapeutic context of Gnmt

Surprisingly, the 4S BP-binding protein, which was previously characterized as the glycine N-methyltransferase, was completely devoid of such an enzymatic activity after purification by Sephacryl gel permeation chromatography [4].

References

Protein profiling of mouse livers with peroxisome proliferator-activated receptor alpha activation. Chu, R., Lim, H., Brumfield, L., Liu, H., Herring, C., Ulintz, P., Reddy, J.K., Davison, M. Mol. Cell. Biol. (2004) [Pubmed]
Altered methionine metabolism in long living Ames dwarf mice. Uthus, E.O., Brown-Borg, H.M. Exp. Gerontol. (2003) [Pubmed]
Mouse glycine N-methyltransferase is sexually dimorphic and regulated by growth hormone. Aida, K., Tawata, M., Negishi, M., Onaya, T. Horm. Metab. Res. (1997) [Pubmed]
The 4S benzo(a)pyrene-binding protein is not a transcriptional activator of Cyp1a1 gene in Ah receptor-deficient (AHR -/-) transgenic mice. Foussat, J., Costet, P., Galtier, P., Pineau, T., Lesca, P. Arch. Biochem. Biophys. (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP002198	Anopheles gambiae str. PEST
GNMT	Bos taurus
GNMT	Canis lupus familiaris
gnmt	Danio rerio
CG6188	Drosophila melanogaster
GNMT	Homo sapiens
GNMT	Macaca mulatta
GNMT	Pan troglodytes

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.