Gene Review:
Mat1a - methionine adenosyltransferase I, alpha
Mus musculus
Synonyms:
AI046368, AdoMet, AdoMet synthase 1, Ams, MAT, ...
- Resistance to multiple adenine nucleoside and methionine analogues in mutant murine lymphoma cells with enlarged S-adenosylmethionine pools. Kajander, E.O., Kubota, M., Carrera, C.J., Montgomery, J.A., Carson, D.A. Cancer Res. (1986)
- S-adenosylmethionine blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoter. Nieto, N., Cederbaum, A.I. J. Biol. Chem. (2005)
- Reversal of the hypomethylation status of urokinase (uPA) promoter blocks breast cancer growth and metastasis. Pakneshan, P., Szyf, M., Farias-Eisner, R., Rabbani, S.A. J. Biol. Chem. (2004)
- Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death. Migchielsen, A.A., Breuer, M.L., van Roon, M.A., te Riele, H., Zurcher, C., Ossendorp, F., Toutain, S., Hershfield, M.S., Berns, A., Valerio, D. Nat. Genet. (1995)
- Molecular mechanisms of an inborn error of methionine pathway. Methionine adenosyltransferase deficiency. Ubagai, T., Lei, K.J., Huang, S., Mudd, S.H., Levy, H.L., Chou, J.Y. J. Clin. Invest. (1995)
- S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. Prudova, A., Bauman, Z., Braun, A., Vitvitsky, V., Lu, S.C., Banerjee, R. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine. Santamaria, E., Avila, M.A., Latasa, M.U., Rubio, A., Martin-Duce, A., Lu, S.C., Mato, J.M., Corrales, F.J. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Lu, S.C., Alvarez, L., Huang, Z.Z., Chen, L., An, W., Corrales, F.J., Avila, M.A., Kanel, G., Mato, J.M. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Elucidation of the mechanism by which homocysteine potentiates the anti-vaccinia virus effects of the S-adenosylhomocysteine hydrolase inhibitor 9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl)-adenine. Hasobe, M., McKee, J.G., Ishii, H., Cools, M., Borchardt, R.T., De Clercq, E. Mol. Pharmacol. (1989)
- Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase. Bitonti, A.J., Byers, T.L., Bush, T.L., Casara, P.J., Bacchi, C.J., Clarkson, A.B., McCann, P.P., Sjoerdsma, A. Antimicrob. Agents Chemother. (1990)
- Influence of S-adenosylhomocysteine hydrolase inhibitors on S-adenosylhomocysteine and S-adenosylmethionine pool levels in L929 cells. Cools, M., De Clercq, E. Biochem. Pharmacol. (1990)
- Selenite toxicity, depletion of liver S-adenosylmethionine, and inactivation of methionine adenosyltransferase. Hoffman, J.L. Arch. Biochem. Biophys. (1977)
- Cloning and expression of murine S-adenosylmethionine synthetase. Sakata, S.F., Shelly, L.L., Ruppert, S., Schutz, G., Chou, J.Y. J. Biol. Chem. (1993)
- S-adenosylmethionine synthetase is overexpressed in murine neuroblastoma cells resistant to nucleoside analogue inhibitors of S-adenosylhomocysteine hydrolase: a novel mechanism of drug resistance. Dwivedi, R.S., Wang, L.J., Mirkin, B.L. Cancer Res. (1999)
- Structure and organization of the human S-adenosylmethionine decarboxylase gene. Marić, S.C., Crozat, A., Jänne, O.A. J. Biol. Chem. (1992)
- Distal motor axonopathy and central nervous system myelin vacuolation caused by cycloleucine, an inhibitor of methionine adenosyltransferase. Lee, C.C., Surtees, R., Duchen, L.W. Brain (1992)
- Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A. Chen, L., Zeng, Y., Yang, H., Lee, T.D., French, S.W., Corrales, F.J., García-Trevijano, E.R., Avila, M.A., Mato, J.M., Lu, S.C. FASEB J. (2004)
- Synthesis of S-adenosylethionine by the gamma isozyme of methionine adenosyltransferase from Friend erythroleukemic cells. Cox, R., Goorha, S. Cancer Res. (1984)
- Relative abilities of bis(ethyl) derivatives of putrescine, spermidine, and spermine to regulate polyamine biosynthesis and inhibit L1210 leukemia cell growth. Porter, C.W., McManis, J., Casero, R.A., Bergeron, R.J. Cancer Res. (1987)
- S-adenosylmethionine (AdoMet) modulates endotoxin stimulated interleukin-10 production in monocytes. Song, Z., Barve, S., Chen, T., Nelson, W., Uriarte, S., Hill, D., McClain, C. Am. J. Physiol. Gastrointest. Liver Physiol. (2003)
- Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of L-isoaspartyl (D-Aspartyl) O-methyltransferase-deficient mice. Farrar, C., Clarke, S. J. Biol. Chem. (2002)
- Substrate specificity and kinetic mechanism of mammalian G9a histone H3 methyltransferase. Patnaik, D., Chin, H.G., Estève, P.O., Benner, J., Jacobsen, S.E., Pradhan, S. J. Biol. Chem. (2004)
- Modulation of polyamine-biosynthetic activity by S-adenosylmethionine depletion. Kramer, D.L., Sufrin, J.R., Porter, C.W. Biochem. J. (1988)
- Decreased transmethylation of biogenic amines after in vivo elevation of brain S-adenosyl-l-homocysteine. Schatz, R.A., Wilens, T.E., Sellinger, O.Z. J. Neurochem. (1981)
- Regulation of S-adenosylmethionine decarboxylase in L1210 leukemia cells. Studies using an irreversible inhibitor of the enzyme. Autelli, R., Stjernborg, L., Khomutov, A.R., Khomutov, R.M., Persson, L. Eur. J. Biochem. (1991)
- Mechanisms of selenium methylation and toxicity in mice treated with selenocystine. Hasegawa, T., Mihara, M., Nakamuro, K., Sayato, Y. Arch. Toxicol. (1996)
- Acetaminophen-induced suppression of hepatic AdoMet synthetase activity is attenuated by prodrugs of L-cysteine. Shirota, F.N., DeMaster, E.G., Shoeman, D.W., Nagasawa, H.T. Toxicol. Lett. (2002)