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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CILP2  -  cartilage intermediate layer protein 2

Homo sapiens

Synonyms: CILP-2, Cartilage intermediate layer protein 2, MGC45771
 
 
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High impact information on CILP2

  • METHODS: Using primary cultures of articular chondrocytes from the knee, we defined the function of the previously described CILP (CILP-1) and of a recently described 50.6% identical protein that we designated the CILP-2 isoform [1].
  • The 1H NMR analysis of the TCNB complexes 3@1 b and 3@2 a at low temperatures (T<-80 degrees C) showed that 3 undergoes fast rotation inside the cavity of tweezer 1 b or clip 2 a (rotational barrier: DeltaG( not equal)=11.7 and 8.3 kcal mol(-1), respectively) [2].
  • Finally, the bromo substituents in the newly prepared clip 2 b have a substantial effect on the kinetics and thermodynamics of complex formation [2].
  • Clip 2 b forms weaker complexes with (TCNB, 3) and tetracyanoquinodimethane (TCNQ, 12) and a more stable complex with 2,4,7-trinitrofluoren-9-ylidene (TNF, 13) than the parent clip 2 a [2].

References

  1. One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist. Johnson, K., Farley, D., Hu, S.I., Terkeltaub, R. Arthritis Rheum. (2003) [Pubmed]
  2. Dynamics in host-guest complexes of molecular tweezers and clips. Lobert, M., Bandmann, H., Burkert, U., Büchele, U.P., Podsadlowski, V., Klärner, F.G. Chemistry (Weinheim an der Bergstrasse, Germany) (2006) [Pubmed]
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