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Gene Review

CILP  -  cartilage intermediate layer protein,...

Homo sapiens

Synonyms: CILP-1, Cartilage intermediate layer protein 1, Cartilage intermediate-layer protein, HsT18872, UNQ602/PRO1188
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Disease relevance of CILP


High impact information on CILP


Biological context of CILP


Anatomical context of CILP


Associations of CILP with chemical compounds

  • In addition, mice were immunized with a mixture of the C1 and C2 fusion proteins to assess the arthrogenicity of CILP [1].
  • We also find one repeat of this Cys domain in human cartilage intermediate layer protein but find no evidence of this domain in any invertebrate species, including those for which entire genomes have been sequenced [15].
  • Administration of PPA produced a statistically significant increase in MUP and CILPP [16].

Regulatory relationships of CILP

  • We have found that CILP mRNA expression is induced by TGF-beta1 and dependent upon signaling via TGF-beta receptors [2].

Other interactions of CILP


Analytical, diagnostic and therapeutic context of CILP


  1. Implication of cartilage intermediate layer protein in cartilage destruction in subsets of patients with osteoarthritis and rheumatoid arthritis. Tsuruha, J., Masuko-Hongo, K., Kato, T., Sakata, M., Nakamura, H., Nishioka, K. Arthritis Rheum. (2001) [Pubmed]
  2. Transcriptional regulation of the cartilage intermediate layer protein (CILP) gene. Mori, M., Nakajima, M., Mikami, Y., Seki, S., Takigawa, M., Kubo, T., Ikegawa, S. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  3. The prevalence of autoantibodies against cartilage intermediate layer protein, YKL-39, osteopontin, and cyclic citrullinated peptide in patients with early-stage knee osteoarthritis: evidence of a variety of autoimmune processes. Du, H., Masuko-Hongo, K., Nakamura, H., Xiang, Y., Bao, C.D., Wang, X.D., Chen, S.L., Nishioka, K., Kato, T. Rheumatol. Int. (2005) [Pubmed]
  4. Exclusion of the gene for human cartilage intermediate layer protein in currently mapped calcium pyrophosphate dihydrate deposition syndromes. Marinescu, R.C., Nyce, K., Serrano de la Peña, L., Overhauser, J., Williams, C.J. Arthritis Rheum. (1999) [Pubmed]
  5. A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. Seki, S., Kawaguchi, Y., Chiba, K., Mikami, Y., Kizawa, H., Oya, T., Mio, F., Mori, M., Miyamoto, Y., Masuda, I., Tsunoda, T., Kamata, M., Kubo, T., Toyama, Y., Kimura, T., Nakamura, Y., Ikegawa, S. Nat. Genet. (2005) [Pubmed]
  6. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Valdes, A.M., Van Oene, M., Hart, D.J., Surdulescu, G.L., Loughlin, J., Doherty, M., Spector, T.D. Arthritis Rheum. (2006) [Pubmed]
  7. Proteomic surveillance of autoimmunity in osteoarthritis: identification of triosephosphate isomerase as an autoantigen in patients with osteoarthritis. Xiang, Y., Sekine, T., Nakamura, H., Imajoh-Ohmi, S., Fukuda, H., Nishioka, K., Kato, T. Arthritis Rheum. (2004) [Pubmed]
  8. Cloning and deduced amino acid sequence of a novel cartilage protein (CILP) identifies a proform including a nucleotide pyrophosphohydrolase. Lorenzo, P., Neame, P., Sommarin, Y., Heinegård, D. J. Biol. Chem. (1998) [Pubmed]
  9. The human CILP gene: exon/intron organization and chromosomal mapping. Lorenzo, P., Aman, P., Sommarin, Y., Heinegård, D. Matrix Biol. (1999) [Pubmed]
  10. Genomic organization, mapping, and polymorphisms of the gene encoding human cartilage intermediate layer protein (CILP). Nakamura, I., Okawa, A., Ikegawa, S., Takaoka, K., Nakamura, Y. J. Hum. Genet. (1999) [Pubmed]
  11. A novel cartilage protein (CILP) present in the mid-zone of human articular cartilage increases with age. Lorenzo, P., Bayliss, M.T., Heinegård, D. J. Biol. Chem. (1998) [Pubmed]
  12. Characterisation of cartilage intermediate layer protein (CILP)-induced arthropathy in mice. Yao, Z., Nakamura, H., Masuko-Hongo, K., Suzuki-Kurokawa, M., Nishioka, K., Kato, T. Ann. Rheum. Dis. (2004) [Pubmed]
  13. Up-regulated expression of cartilage intermediate-layer protein and ANK in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease. Hirose, J., Ryan, L.M., Masuda, I. Arthritis Rheum. (2002) [Pubmed]
  14. Neoantigens in osteoarthritic cartilage. Kato, T., Xiang, Y., Nakamura, H., Nishioka, K. Current opinion in rheumatology. (2004) [Pubmed]
  15. Molecular patterning of the oikoplastic epithelium of the larvacean tunicate Oikopleura dioica. Spada, F., Steen, H., Troedsson, C., Kallesoe, T., Spriet, E., Mann, M., Thompson, E.M. J. Biol. Chem. (2001) [Pubmed]
  16. Validation of cough-induced leak point pressure measurement in the evaluation of pharmacological treatment of stress incontinence. Siltberg, H., Larsson, G., Hallén, B., Johansson, C., Ulmsten, U. Neurourology and urodynamics. (1999) [Pubmed]
  17. One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist. Johnson, K., Farley, D., Hu, S.I., Terkeltaub, R. Arthritis Rheum. (2003) [Pubmed]
  18. Noncollagenous, nonproteoglycan macromolecules of cartilage. Neame, P.J., Tapp, H., Azizan, A. Cell. Mol. Life Sci. (1999) [Pubmed]
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