Disease relevance of DIRAS1

• Moreover, expression of exogenous Rig in human astrocytoma cells suppressed growth [1].

High impact information on DIRAS1

• We have identified a novel Ras-related protein that suppresses cell growth and have designated it Rig (Ras-related inhibitor of cell growth) [1].
• However, Rig protein expression is frequently lost or down-regulated in neural tumor-derived cell lines and primary human neural tumors [1].
• Overexpression of Rig inhibited Ras-mediated cellular transformation and activation of downstream signaling in NIH 3T3 cells. rig mRNA is expressed at high levels in normal cardiac and neural tissue [1].
• Here we have identified novel Ras members, human Di-Ras1 and Di-Ras2, belonging to a distinct branch of the GTPase family [2].
• These findings raise the possibility that Di-Ras might regulate cell morphogenesis in a manner distinct from other members of Ras family [2].

Biological context of DIRAS1

• 1) Thr-63 and Ser-65 in Di-Ras are substituted for Ala-59 and Gln-61 positions in Ha-Ras, respectively, that are known to be critical for GTP hydrolysis [2].

Other interactions of DIRAS1

• Moreover, Di-Ras fails to interact with the Ras-binding domain of Raf, resulting in no stimulation of mitogen-activated protein kinase [2].

References