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Gene Review

DIRAS1  -  DIRAS family, GTP-binding RAS-like 1

Homo sapiens

Synonyms: Di-Ras1, Distinct subgroup of the Ras family member 1, GBTS1, GTP-binding protein Di-Ras1, RIG, ...


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Disease relevance of DIRAS1

  • Moreover, expression of exogenous Rig in human astrocytoma cells suppressed growth [1].

High impact information on DIRAS1

  • We have identified a novel Ras-related protein that suppresses cell growth and have designated it Rig (Ras-related inhibitor of cell growth) [1].
  • However, Rig protein expression is frequently lost or down-regulated in neural tumor-derived cell lines and primary human neural tumors [1].
  • Overexpression of Rig inhibited Ras-mediated cellular transformation and activation of downstream signaling in NIH 3T3 cells. rig mRNA is expressed at high levels in normal cardiac and neural tissue [1].
  • Here we have identified novel Ras members, human Di-Ras1 and Di-Ras2, belonging to a distinct branch of the GTPase family [2].
  • These findings raise the possibility that Di-Ras might regulate cell morphogenesis in a manner distinct from other members of Ras family [2].

Biological context of DIRAS1

  • 1) Thr-63 and Ser-65 in Di-Ras are substituted for Ala-59 and Gln-61 positions in Ha-Ras, respectively, that are known to be critical for GTP hydrolysis [2].

Other interactions of DIRAS1


  1. Rig is a novel Ras-related protein and potential neural tumor suppressor. Ellis, C.A., Vos, M.D., Howell, H., Vallecorsa, T., Fults, D.W., Clark, G.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Di-Ras, a distinct subgroup of ras family GTPases with unique biochemical properties. Kontani, K., Tada, M., Ogawa, T., Okai, T., Saito, K., Araki, Y., Katada, T. J. Biol. Chem. (2002) [Pubmed]
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