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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Astrocytoma


Psychiatry related information on Astrocytoma


High impact information on Astrocytoma

  • Diagnosis of recurrent astrocytoma with fludeoxyglucose F18 PET scanning [7].
  • Here we show that expression of an endothelial cell-specific mitogen, vascular endothelial growth factor (VEGF), is induced in astrocytoma cells but is dramatically upregulated in two apparently different subsets of glioblastoma cells [8].
  • Inhibiting protein synthesis by incubating C6-2B rat astrocytoma cells with cycloheximide or emetine for periods up to 24 hours caused a progressive decrease in the accumulation of adenosine 3',5'-monophosphate (cyclic AMP) when the cells were challenged for 30 minutes with 100 microM forskolin [9].
  • Incubation of astrocytoma cells with catecholamines results in a decrease in catecholamine-stimulated adenylate cyclase activity and a concomitant alteration in the sedimentation properties of particulate beta-adrenergic receptors [10].
  • We conducted a prospectively randomized trial comparing whole-brain irradiation alone vs identical irradiation plus dianhydrogalactitol in 42 patients with grade 3 and 4 supratentorial astrocytomas [11].

Chemical compound and disease context of Astrocytoma


Biological context of Astrocytoma


Anatomical context of Astrocytoma


Gene context of Astrocytoma


Analytical, diagnostic and therapeutic context of Astrocytoma


  1. Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Reilly, K.M., Loisel, D.A., Bronson, R.T., McLaughlin, M.E., Jacks, T. Nat. Genet. (2000) [Pubmed]
  2. Somatic mutations in the neurofibromatosis 1 gene in human tumors. Li, Y., Bollag, G., Clark, R., Stevens, J., Conroy, L., Fults, D., Ward, K., Friedman, E., Samowitz, W., Robertson, M. Cell (1992) [Pubmed]
  3. The HCMV gene products US11 and US2 differ in their ability to attack allelic forms of murine major histocompatibility complex (MHC) class I heavy chains. Machold, R.P., Wiertz, E.J., Jones, T.R., Ploegh, H.L. J. Exp. Med. (1997) [Pubmed]
  4. Carcinogenicity of nitrosotrialkylureas in Fischer 344 rats. Lijinsky, W., Reuber, M.D., Blackwell, B.N. J. Natl. Cancer Inst. (1980) [Pubmed]
  5. Cell surface glycoproteins of human tumor cell lines: unusual characteristics of malignant melanoma. Lloyd, K.O., Travassos, L.R., Takahashi, T., Old, L.J. J. Natl. Cancer Inst. (1979) [Pubmed]
  6. Neurofibromin in the brain. Gutmann, D.H. J. Child Neurol. (2002) [Pubmed]
  7. Diagnosis of recurrent astrocytoma with fludeoxyglucose F18 PET scanning. Mirzaei, S., Knoll, P., Kohn, H. N. Engl. J. Med. (2001) [Pubmed]
  8. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Plate, K.H., Breier, G., Weich, H.A., Risau, W. Nature (1992) [Pubmed]
  9. Selective reduction of forskolin-stimulated cyclic AMP accumulation by inhibitors of protein synthesis. Brooker, G., Pedone, C., Barovsky, K. Science (1983) [Pubmed]
  10. Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors. Harden, T.K., Cotton, C.U., Waldo, G.L., Lutton, J.K., Perkins, J.P. Science (1980) [Pubmed]
  11. Dianhydrogalactitol and radiation therapy. Treatment of supratentorial glioma. Eagan, R.T., Childs, D.S., Layton, D.D., Laws, E.R., Bisel, H.F., Holbrook, M.A., Fleming, T.R. JAMA (1979) [Pubmed]
  12. Intravenous cefotaxime in children with bacterial meningitis. Belohradsky, B.H., Bruch, K., Geiss, D., Kafetzis, D., Marget, W., Peters, G. Lancet (1980) [Pubmed]
  13. Mepacrine blocks beta-adrenergic agonist-induced desensitization in astrocytoma cells. Mallorga, P., Tallman, J.F., Henneberry, R.C., Hirata, F., Strittmatter, W.T., Axelrod, J. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  14. mRNA coding for neurotransmitter receptors in a human astrocytoma. Matute, C., Arellano, R.O., Conde-Guerri, B., Miledi, R. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  15. Calcium and microtubule dependence for increased ornithine decarboxylase activity stimulated by beta-adrenergic agonists, dibutyryl cyclic AMP, or serum in a rat astrocytoma cell line. Gibbs, J.B., Hsu, C.Y., Terasaki, W.L., Brooker, G. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  16. Acidic triterpenes compromise growth and survival of astrocytoma cell lines by regulating reactive oxygen species accumulation. Martín, R., Carvalho-Tavares, J., Carvalho, J., Ibeas, E., Hernández, M., Ruiz-Gutierrez, V., Nieto, M.L. Cancer Res. (2007) [Pubmed]
  17. Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Van Meir, E.G., Polverini, P.J., Chazin, V.R., Su Huang, H.J., de Tribolet, N., Cavenee, W.K. Nat. Genet. (1994) [Pubmed]
  18. Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain? Saas, P., Walker, P.R., Hahne, M., Quiquerez, A.L., Schnuriger, V., Perrin, G., French, L., Van Meir, E.G., de Tribolet, N., Tschopp, J., Dietrich, P.Y. J. Clin. Invest. (1997) [Pubmed]
  19. Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects. Reilly, K.M., Tuskan, R.G., Christy, E., Loisel, D.A., Ledger, J., Bronson, R.T., Smith, C.D., Tsang, S., Munroe, D.J., Jacks, T. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  20. An acid phosphatase in the plasma membranes of human astrocytoma showing marked specificity toward phosphotyrosine protein. Leis, J.F., Kaplan, N.O. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  21. Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains. O'Rourke, D.M., Qian, X., Zhang, H.T., Davis, J.G., Nute, E., Meinkoth, J., Greene, M.I. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  22. Reexpression of glial fibrillary acidic protein rescues the ability of astrocytoma cells to form processes in response to neurons. Chen, W.J., Liem, R.K. J. Cell Biol. (1994) [Pubmed]
  23. Structural determinants for recognition and translocation by the anandamide transporter. Piomelli, D., Beltramo, M., Glasnapp, S., Lin, S.Y., Goutopoulos, A., Xie, X.Q., Makriyannis, A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  24. Heterozygosity for the neurofibromatosis 1 (NF1) tumor suppressor results in abnormalities in cell attachment, spreading and motility in astrocytes. Gutmann, D.H., Wu, Y.L., Hedrick, N.M., Zhu, Y., Guha, A., Parada, L.F. Hum. Mol. Genet. (2001) [Pubmed]
  25. 9q34 loss of heterozygosity in a tuberous sclerosis astrocytoma suggests a growth suppressor-like activity also for the TSC1 gene. Carbonara, C., Longa, L., Grosso, E., Borrone, C., Garrè, M.G., Brisigotti, M., Migone, N. Hum. Mol. Genet. (1994) [Pubmed]
  26. Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis. Desbaillets, I., Diserens, A.C., Tribolet, N., Hamou, M.F., Van Meir, E.G. J. Exp. Med. (1997) [Pubmed]
  27. PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme. Smith, J.S., Tachibana, I., Passe, S.M., Huntley, B.K., Borell, T.J., Iturria, N., O'Fallon, J.R., Schaefer, P.L., Scheithauer, B.W., James, C.D., Buckner, J.C., Jenkins, R.B. J. Natl. Cancer Inst. (2001) [Pubmed]
  28. Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance. Maxwell, M., Naber, S.P., Wolfe, H.J., Galanopoulos, T., Hedley-Whyte, E.T., Black, P.M., Antoniades, H.N. J. Clin. Invest. (1990) [Pubmed]
  29. Interleukin-13 receptor alpha 2, EphA2, and Fos-related antigen 1 as molecular denominators of high-grade astrocytomas and specific targets for combinatorial therapy. Wykosky, J., Gibo, D.M., Stanton, C., Debinski, W. Clin. Cancer Res. (2008) [Pubmed]
  30. Accumulation of wild type p53 protein in human astrocytomas. Rubio, M.P., von Deimling, A., Yandell, D.W., Wiestler, O.D., Gusella, J.F., Louis, D.N. Cancer Res. (1993) [Pubmed]
  31. Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine, and prednisone with the eight-drugs-in-1-day regimen. Childrens Cancer Group. Finlay, J.L., Boyett, J.M., Yates, A.J., Wisoff, J.H., Milstein, J.M., Geyer, J.R., Bertolone, S.J., McGuire, P., Cherlow, J.M., Tefft, M. J. Clin. Oncol. (1995) [Pubmed]
  32. Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study. Jaeckle, K.A., Eyre, H.J., Townsend, J.J., Schulman, S., Knudson, H.M., Belanich, M., Yarosh, D.B., Bearman, S.I., Giroux, D.J., Schold, S.C. J. Clin. Oncol. (1998) [Pubmed]
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