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Gsta1  -  glutathione S-transferase, alpha 1 (Ya)

Mus musculus

Synonyms: GST class-alpha member 1, Glutathione S-transferase A1, Glutathione S-transferase Ya, Glutathione S-transferase Ya1, Gst2-1, ...
 
 
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High impact information on Gsta1

  • This suggests that the variation in inducibility of NQO1, Gsta1/2, and GCS(h) in the mutant mouse is not attributable to the expression of the enzymes in distinct cell types but rather to differences in the dependency of these genes on Nrf2 for induction [1].
  • Glucocorticoids (GCs) repress both basal and polyaromatic hydrocarbon-induced expression of the glutathione S-transferase Ya1 gene (gstA2) in isolated rat hepatocytes and rat liver in vivo [2].
  • Treatment of mice with I3C resulted in the induction of immunoreactive GST mu and GST Ya1 Ya1 [3].
  • Regulation of mouse glutathione S-transferases by chemoprotectors. Molecular evidence for the existence of three distinct alpha-class glutathione S-transferase subunits, Ya1, Ya2, and Ya3, in mouse liver [4].
  • The amino acid sequence of the Ya1 subunit was compared with sequences deduced from a genomic clone, lambda mYa1 (Daniel, Sharon, Tichauer & Sarid (1987) DNA 6, 317-324], and a cDNA clone, pGT41 [Pearson, Reinhart, Sisk, Anderson & Adler (1988) J [4].
 

Associations of Gsta1 with chemical compounds

  • One of the most highly up-regulated genes was glutathione S-transferase, alpha 1 (Ya) (Gsta1), which has recently been shown to participate in Nrf2 regulation and is considered to be related to detoxification response [5].
  • In addition to these constitutively expressed GSTs, we have identified enzymes containing Ya1 (Mr 25,600), Ya2 (Mr 25,600), Yb2 (Mr 26,200) and Yb5 (Mr 26,500) subunits from the livers of Balb/c mice fed on diets containing butylated hydroxyanisole (BHA) [6].
 

Other interactions of Gsta1

  • This enzyme (designated GST Ya1 Ya1) did not bind to either the S-hexylglutathione-Sepharose or the glutathione-Sepharose affinity matrices, and purification was achieved by using bromosulphophthalein-glutathione-Sepharose [7].

References

  1. The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. McMahon, M., Itoh, K., Yamamoto, M., Chanas, S.A., Henderson, C.J., McLellan, L.I., Wolf, C.R., Cavin, C., Hayes, J.D. Cancer Res. (2001) [Pubmed]
  2. Negative regulation of the rat glutathione S-transferase A2 gene by glucocorticoids involves a canonical glucocorticoid consensus sequence. Falkner, K.C., Rushmore, T.H., Linder, M.W., Prough, R.A. Mol. Pharmacol. (1998) [Pubmed]
  3. Photoaffinity labelling of steroid-hormone-binding glutathione S-transferases with [3H]methyltrienolone. Inhibition of steroid-binding activity by the anticarcinogen indole-3-carbinol. Danger, D.P., Baldwin, W.S., LeBlanc, G.A. Biochem. J. (1992) [Pubmed]
  4. Regulation of mouse glutathione S-transferases by chemoprotectors. Molecular evidence for the existence of three distinct alpha-class glutathione S-transferase subunits, Ya1, Ya2, and Ya3, in mouse liver. McLellan, L.I., Kerr, L.A., Cronshaw, A.D., Hayes, J.D. Biochem. J. (1991) [Pubmed]
  5. Global gene expression analyses of mouse fibroblast L929 cells exposed to IC50 MMA by DNA microarray and confirmation of four detoxification genes' expression by real-time PCR. Ishikawa, A., Jinno, S., Suzuki, T., Hayashi, T., Kawai, T., Mizuno, T., Mori, T., Hattori, M. Dental materials journal. (2006) [Pubmed]
  6. Hepatic glutathione S-transferases in mice fed on a diet containing the anticarcinogenic antioxidant butylated hydroxyanisole. Isolation of mouse glutathione S-transferase heterodimers by gradient elution of the glutathione-Sepharose affinity matrix. Hayes, J.D., Kerr, L.A., Peacock, S.D., Cronshaw, A.D., McLellan, L.I. Biochem. J. (1991) [Pubmed]
  7. Differential induction of class alpha glutathione S-transferases in mouse liver by the anticarcinogenic antioxidant butylated hydroxyanisole. Purification and characterization of glutathione S-transferase Ya1Ya1. McLellan, L.I., Hayes, J.D. Biochem. J. (1989) [Pubmed]
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