High impact information on Gsta3

• Retrovirus-mediated gene transfer of rat glutathione S-transferase Yc confers alkylating drug resistance in NIH 3T3 mouse fibroblasts [1].
• Retrovirus-mediated gene transfer of rat glutathione S-transferase Yc confers in vitro resistance to alkylating agents in human leukemia cells and in clonogenic mouse hematopoietic progenitor cells [2].
• Expression of the GSTYc transcript was not detected in testis or uterus [3].
• A cDNA encoding alpha-class glutathione S-transferase Yc (GSTYc) has been isolated from a Syrian hamster kidney library, and its nucleotide sequence (968 bp) has been determined [3].
• A GSTYc mRNA of approx. 1 kb is expressed in liver, kidney, vas deferens and epididymis [3].

Associations of Gsta3 with chemical compounds

• Regulation of mouse glutathione S-transferases by chemoprotectors. Molecular evidence for the existence of three distinct alpha-class glutathione S-transferase subunits, Ya1, Ya2, and Ya3, in mouse liver [4].
• Hepatic concentrations of GST Ya3 Ya3 were not significantly affected when mice were treated with butylated hydroxyanisole [5].

Regulatory relationships of Gsta3

• The soluble hepatic GSTs expressed by mice fed on normal diets are all homodimers comprising Ya3 (Mr 25,800), Yb1 (Mr 26,400) and Yf (Mr 24,800) subunits [6].

Analytical, diagnostic and therapeutic context of Gsta3

• Molecular cloning and heterologous expression of a cDNA encoding a mouse glutathione S-transferase Yc subunit possessing high catalytic activity for aflatoxin B1-8,9-epoxide [7].
• Northern-blot experiments demonstrated that Syrian hamster GSTYc expression is tissue-specific [3].

References