Gene Review:
Gsta4 - glutathione S-transferase, alpha 4
Mus musculus
Synonyms:
GST 5.7, GST A4-4, GST class-alpha member 4, GST5.7, GSTA4-4, ...
- Status of antioxidant defense system and expression of toxicant responsive genes in striatum of maneb- and paraquat-induced Parkinson's disease phenotype in mouse: Mechanism of neurodegeneration. Patel, S., Singh, V., Kumar, A., Gupta, Y.K., Singh, M.P. Brain Res. (2006)
- Prominent free radicals scavenging activity of tannic acid in lead-induced oxidative stress in experimental mice. El-Sayed, I.H., Lotfy, M., El-Khawaga, O.A., Nasif, W.A., El-Shahat, M. Toxicology and industrial health. (2006)
- Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse. Engle, M.R., Singh, S.P., Czernik, P.J., Gaddy, D., Montague, D.C., Ceci, J.D., Yang, Y., Awasthi, S., Awasthi, Y.C., Zimniak, P. Toxicol. Appl. Pharmacol. (2004)
- Principal drug-metabolizing enzyme systems in L1210 leukemia sensitive or resistant to BCNU in vivo. Ribrag, V., Massaad, L., Janot, F., Bissery, M.C., Parise, O., Gouyette, A., Chabot, G.G. Leuk. Res. (1994)
- Antiproliferative effects of the somatostatin analogue octreotide (SMS 201-995) on ZR-75-1 human breast cancer cells in vivo and in vitro. Weckbecker, G., Liu, R., Tolcsvai, L., Bruns, C. Cancer Res. (1992)
- The type B leukemogenic virus truncated superantigen is dispensable for T-cell lymphomagenesis. Mustafa, F., Bhadra, S., Johnston, D., Lozano, M., Dudley, J.P. J. Virol. (2003)
- Iron-induced lipid peroxidation in rat liver is accompanied by preferential induction of glutathione S-transferase 8-8 isozyme. Khan, M.F., Srivastava, S.K., Singhal, S.S., Chaubey, M., Awasthi, S., Petersen, D.R., Ansari, G.A., Awasthi, Y.C. Toxicol. Appl. Pharmacol. (1995)
- Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo. Scherzinger, E., Lurz, R., Turmaine, M., Mangiarini, L., Hollenbach, B., Hasenbank, R., Bates, G.P., Davies, S.W., Lehrach, H., Wanker, E.E. Cell (1997)
- A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains. Steinmetz, M., Moore, K.W., Frelinger, J.G., Sher, B.T., Shen, F.W., Boyse, E.A., Hood, L. Cell (1981)
- Glutathione transferases. Hayes, J.D., Flanagan, J.U., Jowsey, I.R. Annu. Rev. Pharmacol. Toxicol. (2005)
- Hybridization of alpha class subunits generating a functional glutathione transferase A1-4 heterodimer. Gustafsson, A., Nilsson, L.O., Mannervik, B. J. Mol. Biol. (2002)
- Altered patterns of cutaneous xenobiotic metabolism in UVB-induced squamous cell carcinoma in SKH-1 hairless mice. Das, M., Bickers, D.R., Santella, R.M., Mukhtar, H. J. Invest. Dermatol. (1985)
- Down-regulation of aryl hydrocarbon receptor-regulated genes by tumor necrosis factor-alpha and lipopolysaccharide in murine hepatoma Hepa 1c1c7 cells. Gharavi, N., El-Kadi, A.O. Journal of pharmaceutical sciences. (2005)
- Glutathione S-transferases--biomarkers of cancer risk and chemopreventive response. Clapper, M.L., Szarka, C.E. Chem. Biol. Interact. (1998)
- Fusion of the CH1 domain of IgG1 to epidermal growth factor (EGF) prolongs its retention in the blood but does not increase tumor uptake. Wang, J., Reilly, R.M., Chen, P., Yang, S., Bray, M.R., Gariépy, J., Chan, C., Sandhu, J. Cancer Biother. Radiopharm. (2002)
- Susceptibility to aflatoxin B1-related primary hepatocellular carcinoma in mice and humans. McGlynn, K.A., Hunter, K., LeVoyer, T., Roush, J., Wise, P., Michielli, R.A., Shen, F.M., Evans, A.A., London, W.T., Buetow, K.H. Cancer Res. (2003)
- Crystal structure of a murine glutathione S-transferase in complex with a glutathione conjugate of 4-hydroxynon-2-enal in one subunit and glutathione in the other: evidence of signaling across the dimer interface. Xiao, B., Singh, S.P., Nanduri, B., Awasthi, Y.C., Zimniak, P., Ji, X. Biochemistry (1999)
- Crystal structure of a murine alpha-class glutathione S-transferase involved in cellular defense against oxidative stress. Krengel, U., Schröter, K.H., Hoier, H., Arkema, A., Kalk, K.H., Zimniak, P., Dijkstra, B.W. FEBS Lett. (1998)
- A subgroup of class alpha glutathione S-transferases. Cloning of cDNA for mouse lung glutathione S-transferase GST 5.7. Zimniak, P., Eckles, M.A., Saxena, M., Awasthi, Y.C. FEBS Lett. (1992)
- Partial hepatoprotective effects of allylthiobenzimidazole in the absence of cytochrome P4502E1 suppression: effects on epoxide hydrolase, rGSTA2, rGSTA3/5, rGSTM1 and rGSTM2 expression. Kim, S.G., Lee, A.K., Kim, N.D. Xenobiotica (1998)
- Phosphorylation enhances mitochondrial targeting of GSTA4-4 through increased affinity for binding to cytoplasmic Hsp70. Robin, M.A., Prabu, S.K., Raza, H., Anandatheerthavarada, H.K., Avadhani, N.G. J. Biol. Chem. (2003)
- Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress. Raza, H., Robin, M.A., Fang, J.K., Avadhani, N.G. Biochem. J. (2002)
- Genetic engineering of proteins with cell membrane permeability. Rojas, M., Donahue, J.P., Tan, Z., Lin, Y.Z. Nat. Biotechnol. (1998)
- Characterization of a novel glutathione S-transferase isoenzyme from mouse lung and liver having structural similarity to rat glutathione S-transferase 8-8. Medh, R.D., Saxena, M., Singhal, S.S., Ahmad, H., Awasthi, Y.C. Biochem. J. (1991)
- Characterization of phenotypes in Gstm1-null mice by cytosolic and in vivo metabolic studies using 1,2-dichloro-4-nitrobenzene. Fujimoto, K., Arakawa, S., Shibaya, Y., Miida, H., Ando, Y., Yasumo, H., Hara, A., Uchiyama, M., Iwabuchi, H., Takasaki, W., Manabe, S., Yamoto, T. Drug Metab. Dispos. (2006)
- Anticlastogenic activity of morin against whole body gamma irradiation in Swiss albino mice. Parihar, V.K., Prabhakar, K.R., Veerapur, V.P., Priyadarsini, K.I., Unnikrishnan, M.K., Rao, C.M. Eur. J. Pharmacol. (2007)
- Cytochrome P450 and antioxidant activity in interleukin-6 knockout mice after induction of the acute-phase response. Warren, G.W., van Ess, P.J., Watson, A.M., Mattson, M.P., Blouin, R.A. J. Interferon Cytokine Res. (2001)
- Metabolic inactivation of five glycidyl ethers in lung and liver of humans, rats and mice in vitro. Boogaard, P.J., de Kloe, K.P., Bierau, J., Kuiken, G., Borkulo, P.E., Watson, W.P., van Sittert, N.J. Xenobiotica (2000)
- Effect of the double-stranded polynucleotide complex polyadenylate-polyuridylate (poly A-U) on interleukin-6 production by mouse fibroblasts. Pignol, B., Maisonnet, T., Mencia-Huerta, J.M., Braquet, P. Immunopharmacology (1991)
- Protective effect of black tea extract on the levels of lipid peroxidation and antioxidant enzymes in liver of mice with pesticide-induced liver injury. Khan, S.M. Cell Biochem. Funct. (2006)
- The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. McMahon, M., Itoh, K., Yamamoto, M., Chanas, S.A., Henderson, C.J., McLellan, L.I., Wolf, C.R., Cavin, C., Hayes, J.D. Cancer Res. (2001)
- Isolation, characterization, and expression in Escherichia coli of two murine Mu class glutathione S-transferase cDNAs homologous to the rat subunits 3 (Yb1) and 4 (Yb2). Townsend, A.J., Goldsmith, M.E., Pickett, C.B., Cowan, K.H. J. Biol. Chem. (1989)
- Photoaffinity labelling of steroid-hormone-binding glutathione S-transferases with [3H]methyltrienolone. Inhibition of steroid-binding activity by the anticarcinogen indole-3-carbinol. Danger, D.P., Baldwin, W.S., LeBlanc, G.A. Biochem. J. (1992)
- Depletion of colonic detoxication enzyme activity in mice with dextran sulphate sodium-induced colitis. Clapper, M.L., Adrian, R.H., Pfeiffer, G.R., Kido, K., Everley, L., Cooper, H.S., Murthy, S. Aliment. Pharmacol. Ther. (1999)