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Gene Review:

UL6 - dodecamer located at one capsid vertex in...

Human herpesvirus 2

Weller, S.K. et al., Ogasawara, M. et al., Newcomb, W.W. et al.

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Disease relevance of UL6

Recent studies have suggested that the herpes simplex type 1 (HSV-1) UL25 gene product, a minor capsid protein, is required for encapsidation but not cleavage of replicated viral DNA [1].
Biochemical analyses revealed partial loss of the minor capsid proteins VP19 and VP23 in G2.0 compared to control capsids [2].

High impact information on UL6

Several HSV-1 proteins including the major capsid protein (VP5), two minor capsid proteins (VP11-12 and VP18.8), the alkaline nuclease and glycoprotein gH have been reported to be encoded by the left-most one-third of HSV-1 UL DNA [3].

References

Role of the UL25 gene product in packaging DNA into the herpes simplex virus capsid: location of UL25 product in the capsid and demonstration that it binds DNA. Ogasawara, M., Suzutani, T., Yoshida, I., Azuma, M. J. Virol. (2001) [Pubmed]
Structure of the herpes simplex virus capsid. Molecular composition of the pentons and the triplexes. Newcomb, W.W., Trus, B.L., Booy, F.P., Steven, A.C., Wall, J.S., Brown, J.C. J. Mol. Biol. (1993) [Pubmed]
Genetic and phenotypic characterization of mutants in four essential genes that map to the left half of HSV-1 UL DNA. Weller, S.K., Carmichael, E.P., Aschman, D.P., Goldstein, D.J., Schaffer, P.A. Virology (1987) [Pubmed]

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