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UL19  -  6 copies form hexons, 5 copies form pentons

Human herpesvirus 2

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Disease relevance of UL19


High impact information on UL19


Chemical compound and disease context of UL19

  • Hexon-only binding of VP26 reflects differences between the hexon and penton conformations of VP5, the major capsid protein of herpes simplex virus [10].
  • Several HSV-1 proteins including the major capsid protein (VP5), two minor capsid proteins (VP11-12 and VP18.8), the alkaline nuclease and glycoprotein gH have been reported to be encoded by the left-most one-third of HSV-1 UL DNA [11].

Biological context of UL19


Anatomical context of UL19


Associations of UL19 with chemical compounds

  • Treatment of HSV-infected BHK-21 cells with 5-10 mM of beta-hydroxynorvaline (Hnv), an analog of threonine which blocked attachment of oligosaccharides at the Asn-X-Thr sites, markedly inhibited the synthesis of all viral glycoproteins as well as the major capsid protein [18].

Analytical, diagnostic and therapeutic context of UL19


  1. Alterations in virus protein synthesis and capsid production in infection with DI particles of herpesvirus. Henry, B.E., Newcomb, W.W., O'Callaghan, D.J. J. Gen. Virol. (1980) [Pubmed]
  2. Simian agent 8--a herpes simplex-like monkey virus. Borchers, K., Ludwig, H. Comp. Immunol. Microbiol. Infect. Dis. (1991) [Pubmed]
  3. Transactivation of a late herpes simplex virus promoter. Dennis, D., Smiley, J.R. Mol. Cell. Biol. (1984) [Pubmed]
  4. Transactivation of the major capsid protein gene of herpes simplex virus type 1 requires a cellular transcription factor. Chen, S., Mills, L., Perry, P., Riddle, S., Wobig, R., Lown, R., Millette, R.L. J. Virol. (1992) [Pubmed]
  5. Mutational analysis of the herpes simplex virus triplex protein VP19C. Adamson, W.E., McNab, D., Preston, V.G., Rixon, F.J. J. Virol. (2006) [Pubmed]
  6. Lytic replication of Kaposi's sarcoma-associated herpesvirus results in the formation of multiple capsid species: isolation and molecular characterization of A, B, and C capsids from a gammaherpesvirus. Nealon, K., Newcomb, W.W., Pray, T.R., Craik, C.S., Brown, J.C., Kedes, D.H. J. Virol. (2001) [Pubmed]
  7. CD4 T-cell responses to herpes simplex virus type 2 major capsid protein VP5: comparison with responses to tegument and envelope glycoproteins. Koelle, D.M., Schomogyi, M., McClurkan, C., Reymond, S.N., Chen, H.B. J. Virol. (2000) [Pubmed]
  8. Evidence that herpes simplex virus VP16 is required for viral egress downstream of the initial envelopment event. Mossman, K.L., Sherburne, R., Lavery, C., Duncan, J., Smiley, J.R. J. Virol. (2000) [Pubmed]
  9. Virus-specific interaction between the human cytomegalovirus major capsid protein and the C terminus of the assembly protein precursor. Beaudet-Miller, M., Zhang, R., Durkin, J., Gibson, W., Kwong, A.D., Hong, Z. J. Virol. (1996) [Pubmed]
  10. Hexon-only binding of VP26 reflects differences between the hexon and penton conformations of VP5, the major capsid protein of herpes simplex virus. Wingfield, P.T., Stahl, S.J., Thomsen, D.R., Homa, F.L., Booy, F.P., Trus, B.L., Steven, A.C. J. Virol. (1997) [Pubmed]
  11. Genetic and phenotypic characterization of mutants in four essential genes that map to the left half of HSV-1 UL DNA. Weller, S.K., Carmichael, E.P., Aschman, D.P., Goldstein, D.J., Schaffer, P.A. Virology (1987) [Pubmed]
  12. Nuclear localization of herpesvirus proteins: potential role for the cellular framework. Quinlan, M.P., Knipe, D.M. Mol. Cell. Biol. (1983) [Pubmed]
  13. Herpes simplex virus capsids assembled in insect cells infected with recombinant baculoviruses: structural authenticity and localization of VP26. Trus, B.L., Homa, F.L., Booy, F.P., Newcomb, W.W., Thomsen, D.R., Cheng, N., Brown, J.C., Steven, A.C. J. Virol. (1995) [Pubmed]
  14. Architecture of the herpes simplex virus major capsid protein derived from structural bioinformatics. Baker, M.L., Jiang, W., Bowman, B.R., Zhou, Z.H., Quiocho, F.A., Rixon, F.J., Chiu, W. J. Mol. Biol. (2003) [Pubmed]
  15. Definition of a series of stages in the association of two herpesviral proteins with the cell nucleus. Knipe, D.M., Spang, A.E. J. Virol. (1982) [Pubmed]
  16. Modifications of the nuclear envelope of BHK cells after infection with herpes simplex virus type 1. Bibor-Hardy, V., Suh, M., Pouchelet, M., Simard, R. J. Gen. Virol. (1982) [Pubmed]
  17. Herpes simplex virus and protein transport are associated with the cytoskeletal framework and the nuclear matrix in infected BSC-1 cells. Ben-Ze'ev, A., Abulafia, R., Bratosin, S. Virology (1983) [Pubmed]
  18. Inhibition of synthesis of herpesvirus (HSV-1) glycoproteins and endogenous fusion by beta-hydroxynorvaline in BHK-21 cells. Kumarasamy, R., Blough, H.A. Virology (1984) [Pubmed]
  19. The large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) is associated with the virion tegument and has PK activity. Smith, C.C., Aurelian, L. Virology (1997) [Pubmed]
  20. Prokaryotic expression of the major capsid protein of human cytomegalovirus and antigenic cross-reactions with herpes simplex virus type 1. Rudolph, S.A., Kühn, J.E., Korn, K., Braun, R.W., Jahn, G. J. Gen. Virol. (1990) [Pubmed]
  21. Herpesvirus in localized juvenile periodontitis. Ting, M., Contreras, A., Slots, J. J. Periodont. Res. (2000) [Pubmed]
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