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Gene Review: 

UL41  -  mRNA-specific RNase

Macacine herpesvirus 1

 
 
 
 
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Disease relevance of UL41

  • The ability of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2, respectively) to repress host cell protein synthesis early in infection has been studied extensively and found to involve the activities of the UL41 gene product, the virion-associated host shutoff (vhs) protein [1].
  • To date, UL41 homologs have been identified in the genomes of three other alphaherpesviruses: equine herpesvirus 1 (EHV-1), varicella-zoster virus, and pseudorabies virus, but very little is known about the putative products of these homologous genes [1].

References

  1. Expression and function of the equine herpesvirus 1 virion-associated host shutoff homolog. Feng, X., Thompson, Y.G., Lewis, J.B., Caughman, G.B. J. Virol. (1996) [Pubmed]
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