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MeSH Review

Herpesvirus 1, Equid

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Disease relevance of Herpesvirus 1, Equid


High impact information on Herpesvirus 1, Equid


Chemical compound and disease context of Herpesvirus 1, Equid

  • There have been conflicting reports regarding the gene assignment of the high-molecular-mass envelope glycoprotein gp2 (gp300) of equine herpesvirus 1 [9].
  • A 1.4-kb mRNA appears initially at 2 h postinfection and is an early transcript since its synthesis is not affected by the presence of phosphonoacetic acid, an inhibitor of EHV-1 DNA replication [10].
  • Effective chemotherapy of equine herpesvirus 1 by phosphonylmethoxyalkyl derivatives of adenine demonstrated in a novel murine model for the disease [11].
  • One interpretation of these data is that EHV-1 gB is cleaved internally at both sites, a possibility which was supported by the apparent molecular masses of the unglycosylated gB subunits produced in the presence of tunicamycin [12].
  • Induction of deoxythymidine kinase activity in several mammalian cell lines after infection with six different strains of equine herpesvirus type 1 (EHV-1) [13].

Biological context of Herpesvirus 1, Equid


Anatomical context of Herpesvirus 1, Equid

  • IL-2 and equine chorionic gonadotrophin (eCG) initiated reactivation of equid herpesvirus-1 (EHV-1) from venous lymphocytes at a frequency of 1/10(-5) [19].
  • Transfer of supernatants showed that IL-2 and eCG acted indirectly by causing the release of other mediators from adherent cells; these mediators then reactivated EHV-1 from T cells [19].
  • In vitro reactivation of latent equid herpesvirus-1 from CD5+/CD8+ leukocytes indirectly by IL-2 or chorionic gonadotrophin [19].
  • Our results suggest that, in common with other alpha-herpesviruses, EHV-1 can establish latency in central nervous system neurons and that the unique membrane glycoprotein encoded by EHV-1 gene 71 is nonessential for infection of neural tissues [20].
  • These data show that the SMAA system is an effective way of presenting subviral components to the immune system and further emphasises the importance of including glycoprotein D as a component of a subunit EHV-1 vaccine [21].

Gene context of Herpesvirus 1, Equid


Analytical, diagnostic and therapeutic context of Herpesvirus 1, Equid


  1. The equine herpesvirus 1 glycoprotein gp21/22a, the herpes simplex virus type 1 gM homolog, is involved in virus penetration and cell-to-cell spread of virions. Osterrieder, N., Neubauer, A., Brandmuller, C., Braun, B., Kaaden, O.R., Baines, J.D. J. Virol. (1996) [Pubmed]
  2. Expression in recombinant vaccinia virus of the equine herpesvirus 1 gene encoding glycoprotein gp13 and protection of immunized animals. Guo, P.X., Goebel, S., Davis, S., Perkus, M.E., Languet, B., Desmettre, P., Allen, G., Paoletti, E. J. Virol. (1989) [Pubmed]
  3. Use of lambda gt11 and monoclonal antibodies to map the genes for the six major glycoproteins of equine herpesvirus 1. Allen, G.P., Yeargan, M.R. J. Virol. (1987) [Pubmed]
  4. Evolution of the herpes thymidine kinase: identification and comparison of the equine herpesvirus 1 thymidine kinase gene reveals similarity to a cell-encoded thymidylate kinase. Robertson, G.R., Whalley, J.M. Nucleic Acids Res. (1988) [Pubmed]
  5. The equine herpesvirus 1 UL20 product interacts with glycoprotein K and promotes egress of mature particles. Guggemoos, S., Just, F.T., Neubauer, A. J. Virol. (2006) [Pubmed]
  6. A negative regulatory element (base pairs -204 to -177) of the EICP0 promoter of equine herpesvirus 1 abolishes the EICP0 protein's trans-activation of its own promoter. Kim, S.K., Albrecht, R.A., O'Callaghan, D.J. J. Virol. (2004) [Pubmed]
  7. Interaction of the equine herpesvirus 1 EICP0 protein with the immediate-early (IE) protein, TFIIB, and TBP may mediate the antagonism between the IE and EICP0 proteins. Kim, S.K., Jang, H.K., Albrecht, R.A., Derbigny, W.A., Zhang, Y., O'Callaghan, D.J. J. Virol. (2003) [Pubmed]
  8. Mapping the sequences that mediate interaction of the equine herpesvirus 1 immediate-early protein and human TFIIB. Jang, H.K., Albrecht, R.A., Buczynski, K.A., Kim, S.K., Derbigny, W.A., O'Callaghan, D.J. J. Virol. (2001) [Pubmed]
  9. The highly O-glycosylated glycoprotein gp2 of equine herpesvirus 1 is encoded by gene 71. Wellington, J.E., Allen, G.P., Gooley, A.A., Love, D.N., Packer, N.H., Yan, J.X., Whalley, J.M. J. Virol. (1996) [Pubmed]
  10. ICP22 homolog of equine herpesvirus 1: expression from early and late promoters. Holden, V.R., Yalamanchili, R.R., Harty, R.N., O'Callaghan, D.J. J. Virol. (1992) [Pubmed]
  11. Effective chemotherapy of equine herpesvirus 1 by phosphonylmethoxyalkyl derivatives of adenine demonstrated in a novel murine model for the disease. Field, H.J., Awan, A.R. Antimicrob. Agents Chemother. (1990) [Pubmed]
  12. N-terminal sequence analysis of equine herpesvirus 1 glycoproteins D and B and evidence for internal cleavage of the gene 71 product. Wellington, J.E., Gooley, A.A., Love, D.N., Whalley, J.M. J. Gen. Virol. (1996) [Pubmed]
  13. Induction of deoxythymidine kinase activity in several mammalian cell lines after infection with six different strains of equine herpesvirus type 1 (EHV-1). Allen, G.P., McGowan, J.J., Bryans, J.T., Randall, C.C., Gentry, G.A. Virology (1978) [Pubmed]
  14. Expression of the full-length form of gp2 of equine herpesvirus 1 (EHV-1) completely restores respiratory virulence to the attenuated EHV-1 strain KyA in CBA mice. Smith, P.M., Kahan, S.M., Rorex, C.B., von Einem, J., Osterrieder, N., O'Callaghan, D.J. J. Virol. (2005) [Pubmed]
  15. Characterization of the trans-activation properties of equine herpesvirus 1 EICP0 protein. Bowles, D.E., Kim, S.K., O'Callaghan, D.J. J. Virol. (2000) [Pubmed]
  16. Polymorphism of open reading frame 71 of equine herpesvirus-4 (EHV-4) and EHV-1. Huang Ja, J.A., Ficorilli, N., Hartley, C.A., Allen, G.P., Studdert, M.J. J. Gen. Virol. (2002) [Pubmed]
  17. Characterization of the major glycoproteins of equine herpesviruses 4 and 1 and asinine herpesvirus 3 using monoclonal antibodies. Crabb, B.S., Allen, G.P., Studdert, M.J. J. Gen. Virol. (1991) [Pubmed]
  18. Identification and control of the cis-acting elements of the immediate early gene of equid herpesvirus type 1. Purewal, A.S., Smallwood, A.V., Kaushal, A., Adegboye, D., Edington, N. J. Gen. Virol. (1992) [Pubmed]
  19. In vitro reactivation of latent equid herpesvirus-1 from CD5+/CD8+ leukocytes indirectly by IL-2 or chorionic gonadotrophin. Smith, D.J., Iqbal, J., Purewal, A., Hamblin, A.S., Edington, N. J. Gen. Virol. (1998) [Pubmed]
  20. Demonstration of equine herpesvirus-1 neuronal latency in murine olfactory bulbs using a novel combined in situ PCR and protein synthesis method. Marshall, K.R., Field, H.J. Virology (1997) [Pubmed]
  21. Solid matrix-antibody-antigen complexes incorporating equine herpesvirus 1 glycoproteins C and D elicit anti-viral immune responses in BALB/c (H-2K(d)) and C3H (H-2K(k)) mice. Alber, D.G., Killington, R.A., Stokes, A. Vaccine (2000) [Pubmed]
  22. Severe murine lung immunopathology elicited by the pathogenic equine herpesvirus 1 strain RacL11 correlates with early production of macrophage inflammatory proteins 1alpha, 1beta, and 2 and tumor necrosis factor alpha. Smith, P.M., Zhang, Y., Grafton, W.D., Jennings, S.R., O'Callaghan, D.J. J. Virol. (2000) [Pubmed]
  23. ICP27 immediate early gene, glycoprotein K (gK) and DNA helicase homologues of infectious laryngotracheitis virus (gallid herpesvirus 1) SA-2 strain. Johnson, M.A., Prideaux, C.T., Kongsuwan, K., Tyack, S.G., Sheppard, M. Arch. Virol. (1995) [Pubmed]
  24. The catalytic subunit of herpes simplex virus type 1 DNA polymerase contains a nuclear localization signal in the UL42-binding region. Loregian, A., Piaia, E., Cancellotti, E., Papini, E., Marsden, H.S., Palù, G. Virology (2000) [Pubmed]
  25. A prime-boost immunization strategy with DNA and recombinant baculovirus-expressed protein enhances protective immunogenicity of glycoprotein D of equine herpesvirus 1 in naïve and infection-primed mice. Ruitenberg, K.M., Walker, C., Love, D.N., Wellington, J.E., Whalley, J.M. Vaccine (2000) [Pubmed]
  26. Transcriptional and translational analyses of the UL2 gene of equine herpesvirus 1: a homolog of UL55 of herpes simplex virus type 1 that is maintained in the genome of defective interfering particles. Harty, R.N., Holden, V.R., O'Callaghan, D.J. J. Virol. (1993) [Pubmed]
  27. Sequence analysis of a glycoprotein D gene homolog within the unique short segment of the EHV-1 genome. Flowers, C.C., Eastman, E.M., O'Callaghan, D.J. Virology (1991) [Pubmed]
  28. Identification and characterization of an equine herpesvirus 1 late gene encoding a potential zinc finger. Holden, V.R., Yalamanchili, R.R., Harty, R.N., O'Callaghan, D.J. Virology (1992) [Pubmed]
  29. Protection against EHV-1 challenge infection in the murine model after vaccination with various formulations of recombinant glycoprotein gp14 (gB). Osterrieder, N., Wagner, R., Brandmüller, C., Schmidt, P., Wolf, H., Kaaden, O.R. Virology (1995) [Pubmed]
  30. Expression of membrane-bound and secreted forms of equine herpesvirus 1 glycoprotein D by recombinant baculovirus. Flowers, C.C., Flowers, S.P., Sheng, Y., Tarbet, E.B., Jennings, S.R., O'Callaghan, D.J. Virus Res. (1995) [Pubmed]
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