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Gene Review:

L - L-polymerase

Borna disease virus

Cubitt, B. et al., McClure, M.A. et al., Nishino, Y. et al., Hashimoto, Y. et al.

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Disease relevance of L

Comparative sequence analysis indicates that p40 is distantly similar to two different regions in the L-polymerase proteins encoded by paramyxoviruses and rhabdoviruses [1].
Enhanced neurovirulence of borna disease virus variants associated with nucleotide changes in the glycoprotein and L polymerase genes [2].

High impact information on L

Of the six open reading frames of BDV, CTLs to BDV X (p10) and the L-polymerase have never been studied [3].
Intron III-spliced mRNAs have coding capability for two new viral proteins with predicted molecular masses of 8.4 and 165 (p165) kDa. p165 is a deleted form of the BDV L polymerase, containing three RGD motifs and a signal peptide signal that could target it into the secretory pathway [4].

References

Sequence similarity between Borna disease virus p40 and a duplicated domain within the paramyxovirus and rhabdovirus polymerase proteins. McClure, M.A., Thibault, K.J., Hatalski, C.G., Lipkin, W.I. J. Virol. (1992) [Pubmed]
Enhanced neurovirulence of borna disease virus variants associated with nucleotide changes in the glycoprotein and L polymerase genes. Nishino, Y., Kobasa, D., Rubin, S.A., Pletnikov, M.V., Carbone, K.M. J. Virol. (2002) [Pubmed]
Two major histocompatibility complex class I-restricted epitopes of the Borna disease virus p10 protein identified by cytotoxic T lymphocytes induced by DNA-based immunization. Hashimoto, Y., Chen, H.S., Cunningham, C., Malik, T.H., Lai, P.K. J. Virol. (2003) [Pubmed]
Identification and characterization of a new intron in Borna disease virus. Cubitt, B., Ly, C., de la Torre, J.C. J. Gen. Virol. (2001) [Pubmed]

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