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Gene Review:

NIa-VPg -

Sweet potato feathery mottle virus

Tan, Z. et al., Gough, K.H. et al., Langenberg, W.G. et al.

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Disease relevance of NIa-VPg

Glutamate at the -1 position has also been observed at the CI/NIa-VPg junction of pea seed borne mosaic virus and turnip mosaic virus and at the NIb/CP junction of papaya ringspot virus polyproteins [1].

High impact information on NIa-VPg

Eighteen recombination sites were found spaced throughout the 5' two-thirds of the genome, but there were only two in the 3' one-third; thus, 24 and 35 % of the P1 and NIa-VPg gene sequences examined were recombinants, whereas only 1 % of the corresponding NIa-Pro and CP gene sequences were recombinants [2].
TEV NIs are known to contain a bifunctional genome-linked protein-viral proteinase (NIa-VPg) and RNA-dependent RNA polymerase (NIb) [3].

References

Nucleotide sequence of Johnsongrass mosaic potyvirus genomic RNA. Gough, K.H., Shukla, D.D. Intervirology (1993) [Pubmed]
Inter- and intralineage recombinants are common in natural populations of Turnip mosaic virus. Tan, Z., Wada, Y., Chen, J., Ohshima, K. J. Gen. Virol. (2004) [Pubmed]
Immunocytology shows the presence of tobacco etch virus P3 protein in nuclear inclusions. Langenberg, W.G., Zhang, L. J. Struct. Biol. (1997) [Pubmed]

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