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Gene Review:

YFVgp1 - polyprotein precursor

Yellow fever virus

Rice, C.M. et al., Pletnev, A.G. et al., Deubel, V. et al.

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Disease relevance of YFVgp1

This genome organization implies that mature viral proteins are produced by posttranslational cleavage of a polyprotein precursor and has implications for flavivirus RNA replication and for the evolutionary relation of this virus family to other RNA viruses [1].
The polyprotein precursor is proteolytically cleaved, apparently by a mechanism resembling that proposed for the expression of polyproteins of the other flaviviruses, such as yellow fever and Kunjin viruses [2].

High impact information on YFVgp1

The amino acid sequence homology between the structural polyprotein precursor of dengue 2 virus and those of yellow fever and West Nile viruses is 36.5 and 42%, respectively [3].

References

Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution. Rice, C.M., Lenches, E.M., Eddy, S.R., Shin, S.J., Sheets, R.L., Strauss, J.H. Science (1985) [Pubmed]
Nucleotide sequence of the genome and complete amino acid sequence of the polyprotein of tick-borne encephalitis virus. Pletnev, A.G., Yamshchikov, V.F., Blinov, V.M. Virology (1990) [Pubmed]
Nucleotide sequence and deduced amino acid sequence of the structural proteins of dengue type 2 virus, Jamaica genotype. Deubel, V., Kinney, R.M., Trent, D.W. Virology (1986) [Pubmed]

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