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Gene Review

MEI1  -  meiosis inhibitor 1

Homo sapiens

Synonyms: MGC40042, Meiosis defective protein 1, Meiosis inhibitor protein 1, SPATA38
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High impact information on RP5-821D11.2

  • MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis [1].
  • In support of this idea, MEI-1 and MEI-2 physically associate in HeLa cells [1].
  • Although it has been difficult to establish the role of katanin in mitosis, new genetic evidence indicates that a katanin-like protein, MEI-1, plays an essential role in meiosis in C. elegans [2].
  • Biochemical studies using the BTB protein MEL-26 and its genetic target MEI-1 (refs 12, 13) indicate that BTB proteins merge the functional properties of Skp1 and F-box proteins into a single polypeptide [3].

Anatomical context of RP5-821D11.2

  • MEI-1 and MEI-2 antibodies decorate the polar ends of meiotic spindle microtubules and meiotic chromatin [1].


  1. MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis. Srayko, M., Buster, D.W., Bazirgan, O.A., McNally, F.J., Mains, P.E. Genes Dev. (2000) [Pubmed]
  2. Cellular Samurai: katanin and the severing of microtubules. Quarmby, L. J. Cell. Sci. (2000) [Pubmed]
  3. BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J., Harper, J.W. Nature (2003) [Pubmed]
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