Gene Review:
SKP1 - S-phase kinase-associated protein 1
Homo sapiens
Synonyms:
Cyclin-A/CDK2-associated protein p19, EMC19, MGC34403, OCP-2, OCP-II, ...
- Gene Expression Profiling of Sporadic Parkinson's Disease Substantia Nigra Pars Compacta Reveals Impairment of Ubiquitin-Proteasome Subunits, SKP1A, Aldehyde Dehydrogenase, and Chaperone HSC-70. Mandel, S., Grunblatt, E., Riederer, P., Amariglio, N., Jacob-Hirsch, J., Rechavi, G., Youdim, M.B. Ann. N. Y. Acad. Sci. (2005)
- OCP2 exists as a dimer in the organ of Corti. Henzl, M.T., Thalmann, I., Thalmann, R. Hear. Res. (1998)
- Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy. Sano, M., Abdellatif, M., Oh, H., Xie, M., Bagella, L., Giordano, A., Michael, L.H., DeMayo, F.J., Schneider, M.D. Nat. Med. (2002)
- Host-cell positive transcription elongation factor b kinase activity is essential and limiting for HIV type 1 replication. Flores, O., Lee, G., Kessler, J., Miller, M., Schlief, W., Tomassini, J., Hazuda, D. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density. Lee, S., Chen, D.Y., Humphrey, J.S., Gnarra, J.R., Linehan, W.M., Klausner, R.D. Proc. Natl. Acad. Sci. U.S.A. (1996)
- The cell cycle gene SKP1 is regulated by light in postnatal rat brain. Uro-Coste, E., Perret, E., Fonta, C., Mathieu, M., Delisle, M.B., Caput, D., Imbert, M. Brain Res. Mol. Brain Res. (1998)
- Identification of mutations in CUL7 in 3-M syndrome. Huber, C., Dias-Santagata, D., Glaser, A., O'Sullivan, J., Brauner, R., Wu, K., Xu, X., Pearce, K., Wang, R., Uzielli, M.L., Dagoneau, N., Chemaitilly, W., Superti-Furga, A., Dos Santos, H., Mégarbané, A., Morin, G., Gillessen-Kaesbach, G., Hennekam, R., Van der Burgt, I., Black, G.C., Clayton, P.E., Read, A., Le Merrer, M., Scambler, P.J., Munnich, A., Pan, Z.Q., Winter, R., Cormier-Daire, V. Nat. Genet. (2005)
- Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases. Goldenberg, S.J., Cascio, T.C., Shumway, S.D., Garbutt, K.C., Liu, J., Xiong, Y., Zheng, N. Cell (2004)
- Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. Wu, G., Xu, G., Schulman, B.A., Jeffrey, P.D., Harper, J.W., Pavletich, N.P. Mol. Cell (2003)
- CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex. Zheng, J., Yang, X., Harrell, J.M., Ryzhikov, S., Shim, E.H., Lykke-Andersen, K., Wei, N., Sun, H., Kobayashi, R., Zhang, H. Mol. Cell (2002)
- Ubiquitin and SUMO systems in the regulation of mitotic checkpoints. Gutierrez, G.J., Ronai, Z. Trends Biochem. Sci. (2006)
- Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2. Yam, C.H., Ng, R.W., Siu, W.Y., Lau, A.W., Poon, R.Y. Mol. Cell. Biol. (1999)
- Characterization of the cullin and F-box protein partner Skp1. Ng, R.W., Arooz, T., Yam, C.H., Chan, I.W., Lau, A.W., Poon, R.Y. FEBS Lett. (1998)
- Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Wei, W., Ayad, N.G., Wan, Y., Zhang, G.J., Kirschner, M.W., Kaelin, W.G. Nature (2004)
- In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation. Piva, R., Liu, J., Chiarle, R., Podda, A., Pagano, M., Inghirami, G. Mol. Cell. Biol. (2002)
- Multiple Skp1-related proteins in Caenorhabditis elegans: diverse patterns of interaction with Cullins and F-box proteins. Yamanaka, A., Yada, M., Imaki, H., Koga, M., Ohshima, Y., Nakayama, K. Curr. Biol. (2002)
- Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. Chiaur, D.S., Murthy, S., Cenciarelli, C., Parks, W., Loda, M., Inghirami, G., Demetrick, D., Pagano, M. Cytogenet. Cell Genet. (2000)
- CD28 costimulation mediates transcription of SKP2 and CKS1, the substrate recognition components of SCFSkp2 ubiquitin ligase that leads p27kip1 to degradation. Appleman, L.J., Chernova, I., Li, L., Boussiotis, V.A. Cell Cycle (2006)
- Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes. Grünblatt, E., Mandel, S., Jacob-Hirsch, J., Zeligson, S., Amariglo, N., Rechavi, G., Li, J., Ravid, R., Roggendorf, W., Riederer, P., Youdim, M.B. Journal of neural transmission (Vienna, Austria : 1996) (2004)
- Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate. Bornstein, G., Ganoth, D., Hershko, A. Proc. Natl. Acad. Sci. U.S.A. (2006)
- The SCF ubiquitin ligase protein slimb regulates centrosome duplication in Drosophila. Wojcik, E.J., Glover, D.M., Hays, T.S. Curr. Biol. (2000)
- Role of epitope density in the induction of immunity and tolerance with thymus-independent antigens. II. Studies with 2,4-dinitrophenyl conjugates in vivo. Desaymard, C., Howard, J.G. Eur. J. Immunol. (1975)
- Analysis of N-acyl aminonaphthalene sulphonic acid derivatives with potential anti-human immunodeficiency virus activity by thin-layer chromatography and flame ionization detection. Madelaine-Dupuich, C., Azema, J., Escoula, B., Rico, I., Lattes, A. Journal of chromatography. A. (1993)
- Detection of cytoplasmic glycosylation associated with hydroxyproline. West, C.M., van der Wel, H., Blader, I.J. Meth. Enzymol. (2006)
- In vitro osteogenesis from human skin-derived precursor cells. Buranasinsup, S., Sila-Asna, M., Bunyaratvej, N., Bunyaratvej, A. Dev. Growth Differ. (2006)
- Cytoplasmic glycosylation of protein-hydroxyproline and its relationship to other glycosylation pathways. West, C.M., Van Der Wel, H., Sassi, S., Gaucher, E.A. Biochim. Biophys. Acta (2004)
- Genomic organization and chromosomal localization of the human CUL2 gene and the role of von Hippel-Lindau tumor suppressor-binding protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma development. Clifford, S.C., Walsh, S., Hewson, K., Green, E.K., Brinke, A., Green, P.M., Gianelli, F., Eng, C., Maher, E.R. Genes Chromosomes Cancer (1999)
- SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells. Bhattacharya, S., Garriga, J., Calbó, J., Yong, T., Haines, D.S., Graña, X. Oncogene (2003)
- HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin. Fuchs, S.Y., Chen, A., Xiong, Y., Pan, Z.Q., Ronai, Z. Oncogene (1999)
- Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Busino, L., Donzelli, M., Chiesa, M., Guardavaccaro, D., Ganoth, D., Dorrello, N.V., Hershko, A., Pagano, M., Draetta, G.F. Nature (2003)
- OCP1, an F-box protein, co-localizes with OCP2/SKP1 in the cochlear epithelial gap junction region. Henzl, M.T., O'Neal, J., Killick, R., Thalmann, I., Thalmann, R. Hear. Res. (2001)
- Mechanism of cell-cycle control: ligating the ligase. Lin, D.I., Diehl, J.A. Trends Biochem. Sci. (2004)
- Phosphorylation- and Skp1-independent in vitro ubiquitination of E2F1 by multiple ROC-cullin ligases. Ohta, T., Xiong, Y. Cancer Res. (2001)
- Identification of Elongin C and Skp1 sequences that determine Cullin selection. Yan, Q., Kamura, T., Cai, Y., Jin, J., Ivan, M., Mushegian, A., Conaway, R.C., Conaway, J.W. J. Biol. Chem. (2004)
- von Hippel-Lindau disease. Maher, E.R., Kaelin, W.G. Medicine (Baltimore) (1997)
- Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins. Fukuchi, M., Imamura, T., Chiba, T., Ebisawa, T., Kawabata, M., Tanaka, K., Miyazono, K. Mol. Biol. Cell (2001)
- Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint. Lehmann, A., Katayama, S., Harrison, C., Dhut, S., Kitamura, K., McDonald, N., Toda, T. Genes Cells (2004)
- Localization of organ of Corti protein II in the adult and developing gerbil cochlea. Yoho, E.R., Thomopoulos, G.N., Thalmann, I., Thalmann, R., Schulte, B.A. Hear. Res. (1997)
- Interaction of Skp1 with CENP-E at the midbody is essential for cytokinesis. Liu, D., Zhang, N., Du, J., Cai, X., Zhu, M., Jin, C., Dou, Z., Feng, C., Yang, Y., Liu, L., Takeyasu, K., Xie, W., Yao, X. Biochem. Biophys. Res. Commun. (2006)
- Surgical treatment of colon and rectum adenocarcinoma in elderly patients. Vivi, A.A., Lopes, A., Cavalcanti, S.d.e. .F., Rossi, B.M., Marques, L.A. Journal of surgical oncology. (1992)