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Gene Review

Hadh  -  hydroxyacyl-Coenzyme A dehydrogenase

Mus musculus

Synonyms: AA409008, AU019341, AW742602, HCDH, Hadhsc, ...
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Disease relevance of Hadh

  • Rae-38, a cDNA clone isolated from mouse embryonal carcinoma F9 cells, was sequenced, and the deduced RAE-38 protein showed about 86% homology to pig 3-hydroxyacyl CoA dehydrogenase (HCDH; EC [1].

High impact information on Hadh

  • Catalytic activities of these enzymes were present at comparable levels in wild-type (OCTN2(+/+)) and homozygous (OCTN2(-/-)) mouse placentas, with the exception of SCHAD, for which activity was significantly higher in OCTN2(-/-) placentas than in OCTN2(+/+) placentas [2].
  • These data show that placental OCTN2 is obligatory for accumulation of carnitine in placenta and fetus, that fatty acid beta-oxidation enzymes are expressed in placenta, and that reduced carnitine levels up-regulate the expression of SCHAD in placenta [2].
  • This clone can be used to elucidate the regulatory mechanism of HCDH gene expression in mammals [1].


  1. Isolation of a cDNA clone encoding mouse 3-hydroxyacyl CoA dehydrogenase. Nomura, M., Takihara, Y., Shimada, K. Gene (1995) [Pubmed]
  2. Carnitine content and expression of mitochondrial beta-oxidation enzymes in placentas of wild-type (OCTN2(+/+)) and OCTN2 Null (OCTN2(-/-)) Mice. Shekhawat, P.S., Yang, H.S., Bennett, M.J., Carter, A.L., Matern, D., Tamai, I., Ganapathy, V. Pediatr. Res. (2004) [Pubmed]
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