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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Carcinoma, Embryonal

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Disease relevance of Carcinoma, Embryonal


Psychiatry related information on Carcinoma, Embryonal


High impact information on Carcinoma, Embryonal


Chemical compound and disease context of Carcinoma, Embryonal


Biological context of Carcinoma, Embryonal


Anatomical context of Carcinoma, Embryonal


Gene context of Carcinoma, Embryonal

  • To test whether overexpression of APP generates abnormally processed derivatives that affect the viability of neurons, we stably transfected full-length human APP complementary DNA into murine embryonal carcinoma P19 cells [28].
  • Here, we show that in P19 embryonal carcinoma (EC) nuclei, HP1 alpha, beta, and gamma form homo- and heteromers associated with nucleosomal core histones [29].
  • Using F9 embryonal carcinoma (EC) cells and ES-5 embryonic stem (ES) cells as in vitro models, we demonstrate that during the differentiation of these cells towards primitive and parietal endoderm-like phenotypes, PTH/PTHrP-receptor mRNA is induced [30].
  • The retinoblastoma (RB) protein is present at low levels in early mouse embryos and in pluripotent P19 embryonal carcinoma cells; however, the levels of RB rise dramatically in neuroectoderm formed both in embryos and in differentiating cultures of P19 cells [31].
  • The full-length cDNA corresponding to Stra8, a novel gene inducible by retinoic acid (RA) in P19 embryonal carcinoma cells, has been isolated and shown to encode a 45-kD protein [32].

Analytical, diagnostic and therapeutic context of Carcinoma, Embryonal


  1. Epidermal growth factor receptors increase during the differentiation of embryonal carcinoma cells. Rees, A.R., Adamson, E.D., Graham, C.F. Nature (1979) [Pubmed]
  2. Telomerase activity in germ cell cancers and mature teratomas. Albanell, J., Bosl, G.J., Reuter, V.E., Engelhardt, M., Franco, S., Moore, M.A., Dmitrovsky, E. J. Natl. Cancer Inst. (1999) [Pubmed]
  3. Induction of in vitro differentiation of mouse embryonal carcinoma (F9) and erythroleukemia (MEL) cells by herbimycin A, an inhibitor of protein phosphorylation. Kondo, K., Watanabe, T., Sasaki, H., Uehara, Y., Oishi, M. J. Cell Biol. (1989) [Pubmed]
  4. Differential activation of the E2F transcription factor by the adenovirus EIa and EIV products in F9 cells. Boeuf, H., Reimund, B., Jansen-Durr, P., Kédinger, C. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  5. Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonal cells. Ghazal, P., DeMattei, C., Giulietti, E., Kliewer, S.A., Umesono, K., Evans, R.M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  6. Altered activation by calcitonin and inhibition by somatostatin of human embryonal carcinoma cell adenylate cyclase with retinoic acid-induced differentiation. Liapi, C., Anderson, W.B., Evain-Brion, D. Dev. Biol. (1986) [Pubmed]
  7. The amyloid beta-protein of Alzheimer's disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells. Sberna, G., Sáez-Valero, J., Beyreuther, K., Masters, C.L., Small, D.H. J. Neurochem. (1997) [Pubmed]
  8. Inhibition of MAP2 expression affects both morphological and cell division phenotypes of neuronal differentiation. Dinsmore, J.H., Solomon, F. Cell (1991) [Pubmed]
  9. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Okamoto, K., Okazawa, H., Okuda, A., Sakai, M., Muramatsu, M., Hamada, H. Cell (1990) [Pubmed]
  10. The c-Ha-ras oncogene and a tumor promoter activate the polyoma virus enhancer. Wasylyk, C., Imler, J.L., Perez-Mutul, J., Wasylyk, B. Cell (1987) [Pubmed]
  11. Detailed analysis of the mouse H-2Kb promoter: enhancer-like sequences and their role in the regulation of class I gene expression. Kimura, A., Israël, A., Le Bail, O., Kourilsky, P. Cell (1986) [Pubmed]
  12. Lipid composition and lateral diffusion in plasma membranes of teratocarcinoma-derived cell lines. Searls, D.B., Edidin, M. Cell (1981) [Pubmed]
  13. A cell surface glycoprotein involved in the compaction of embryonal carcinoma cells and cleavage stage embryos. Hyafil, F., Morello, D., Babinet, C., Jacob, F. Cell (1980) [Pubmed]
  14. Analyses of the interactions between retinoid-binding proteins and embryonal carcinoma cells. Barkai, U., Sherman, M.I. J. Cell Biol. (1987) [Pubmed]
  15. Sodium butyrate induces histone hyperacetylation and differentiation of murine embryonal carcinoma cells. McCue, P.A., Gubler, M.L., Sherman, M.I., Cohen, B.N. J. Cell Biol. (1984) [Pubmed]
  16. pp60src tyrosine kinase modulates P19 embryonal carcinoma cell fate by inhibiting neuronal but not epithelial differentiation. Schmidt, J.W., Brugge, J.S., Nelson, W.J. J. Cell Biol. (1992) [Pubmed]
  17. States of developmental commitment of a mouse embryonal carcinoma cell line differentiating along a neural pathway. Lang, E., Mazauric-Stüker, M.L., Maelicke, A. J. Cell Biol. (1989) [Pubmed]
  18. Expression of H-2, laminin and SV40 T and TASA on differentiation of transformed murine teratocarcinoma cells. Knowles, B.B., Pan, S., Solter, D., Linnenbach, A., Croce, C., Huebner, K. Nature (1980) [Pubmed]
  19. Induction of altered c-src product during neural differentiation of embryonal carcinoma cells. Lynch, S.A., Brugge, J.S., Levine, J.M. Science (1986) [Pubmed]
  20. Insertion mutagenesis of embryonal carcinoma cells by retroviruses. King, W., Patel, M.D., Lobel, L.I., Goff, S.P., Nguyen-Huu, M.C. Science (1985) [Pubmed]
  21. Expression of chicken vinculin complements the adhesion-defective phenotype of a mutant mouse F9 embryonal carcinoma cell. Samuels, M., Ezzell, R.M., Cardozo, T.J., Critchley, D.R., Coll, J.L., Adamson, E.D. J. Cell Biol. (1993) [Pubmed]
  22. The upstream region of the human homeobox gene HOX3D is a target for regulation by retinoic acid and HOX homeoproteins. Arcioni, L., Simeone, A., Guazzi, S., Zappavigna, V., Boncinelli, E., Mavilio, F. EMBO J. (1992) [Pubmed]
  23. Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells. Simeone, A., Acampora, D., Arcioni, L., Andrews, P.W., Boncinelli, E., Mavilio, F. Nature (1990) [Pubmed]
  24. Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor. Bandara, L.R., La Thangue, N.B. Nature (1991) [Pubmed]
  25. Gene expression in visceral endoderm: a comparison of mutant and wild-type F9 embryonal carcinoma cell differentiation. Rogers, M.B., Watkins, S.C., Gudas, L.J. J. Cell Biol. (1990) [Pubmed]
  26. Carbohydrate structure and cell differentitation: unique properties of fucosyl-glycopeptides isolated from embryonal carcinoma cells. Muramatsu, T., Gachelin, G., Nicolas, J.F., Condamine, H., Jakob, H., Jacob, F. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  27. Inhibition of transcription factor GATA-4 expression blocks in vitro cardiac muscle differentiation. Grépin, C., Robitaille, L., Antakly, T., Nemer, M. Mol. Cell. Biol. (1995) [Pubmed]
  28. Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor. Yoshikawa, K., Aizawa, T., Hayashi, Y. Nature (1992) [Pubmed]
  29. Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins. Nielsen, A.L., Oulad-Abdelghani, M., Ortiz, J.A., Remboutsika, E., Chambon, P., Losson, R. Mol. Cell (2001) [Pubmed]
  30. Parathyroid hormone-related peptide as an endogenous inducer of parietal endoderm differentiation. van de Stolpe, A., Karperien, M., Löwik, C.W., Jüppner, H., Segre, G.V., Abou-Samra, A.B., de Laat, S.W., Defize, L.H. J. Cell Biol. (1993) [Pubmed]
  31. Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins. Slack, R.S., Skerjanc, I.S., Lach, B., Craig, J., Jardine, K., McBurney, M.W. J. Cell Biol. (1995) [Pubmed]
  32. Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene. Oulad-Abdelghani, M., Bouillet, P., Décimo, D., Gansmuller, A., Heyberger, S., Dollé, P., Bronner, S., Lutz, Y., Chambon, P. J. Cell Biol. (1996) [Pubmed]
  33. Multiple antigens as marker substances in germinal tumors of the testis. Wahren, B., Alpert, E., Esposti, P. J. Natl. Cancer Inst. (1977) [Pubmed]
  34. Embryonal carcinoma cells express Qa and Tla class I genes of the major histocompatibility complex. Ostrand-Rosenberg, S., Nickerson, D.A., Clements, V.K., Garcia, E.P., Lamouse-Smith, E., Hood, L., Stroynowski, I. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  35. Mechanism of suppression of the long terminal repeat of Moloney leukemia virus in mouse embryonal carcinoma cells. Tsukiyama, T., Niwa, O., Yokoro, K. Mol. Cell. Biol. (1989) [Pubmed]
  36. Formation of vinculin plaques precedes other cytoskeletal changes during retinoic acid-induced teratocarcinoma cell differentiation. Lehtonen, E., Lehto, V.P., Badley, R.A., Virtanen, I. Exp. Cell Res. (1983) [Pubmed]
  37. Identification of a transposon-related RNA down-regulated by retinoic acid in embryonal carcinoma and embryonic stem cells. Hirose, T., Austin, S.J., Jetten, A.M. Exp. Cell Res. (1995) [Pubmed]
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