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Gene Review:

PP1P - pyrophosphatase (inorganic) 1 pseudogene

Homo sapiens

Peyron, J.F. et al., Prudente, S. et al.

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High impact information on PP1P

Phosphorylation of pp21 and pp23 could also be elicited by the Ca2+ ionophore A23187 and sodium orthovanadate (Na3VO4), two agents that bypass the T-cell-receptor complex and produced an increase in cytosolic Ca2+ concentration [1].
These results show that the Ca2+-dependent phosphorylation of pp21 and pp23 represents an early event in the process of signal transduction through the CD3-Ti receptor complex [1].
These data suggest that the QQ genotype of the ENPP1/PC-1 gene is associated with lower BMI [2].

Anatomical context of PP1P

Incubation of 32P-labelled Jurkat cells with anti-CD3 mAb or PHA induced the phosphorylation of two cytosolic proteins that migrate with apparent Mr values of 21,000 (pp21) and 23,000 (pp23) and pI values of 5.1 and 5.0 respectively [1].

References

Phosphorylation of two cytosolic proteins. An early event of T-cell activation. Peyron, J.F., Aussel, C., Ferrua, B., Häring, H., Fehlmann, M. Biochem. J. (1989) [Pubmed]
The Q121/Q121 Genotype of ENPP1/PC-1 Is Associated with Lower BMI in Non-diabetic Whites. Prudente, S., Chandalia, M., Morini, E., Baratta, R., Dallapiccola, B., Abate, N., Frittitta, L., Trischitta, V. Obesity (Silver Spring, Md.) (2007) [Pubmed]

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