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Chemical Compound Review

DECAVANADATE     trisodium trioxido-oxo-vanadium

Synonyms: CHEMBL179166, CCRIS 9063, CHEBI:35607, S6508_SIGMA, AC1L9RCW, ...
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Disease relevance of SODIUM VANADATE


High impact information on SODIUM VANADATE


Chemical compound and disease context of SODIUM VANADATE


Biological context of SODIUM VANADATE


Anatomical context of SODIUM VANADATE


Associations of SODIUM VANADATE with other chemical compounds


Gene context of SODIUM VANADATE

  • Following protein-tyrosine phosphatase inhibition by sodium vanadate both EGFR expressing Chinese hamster ovary (CHO) and A431 exhibited up to an 8-fold increase in the basal level of Tyr-992 phosphorylation, significantly higher than that seen with Tyr-1173, Tyr-1068, and total EGFR Tyr [30].
  • Both specific inhibitors of p38 MAP kinase and sodium vanadate, a potent protein-tyrosine phosphatase inhibitor, blocked IL-8 production in a dose-dependent manner [31].
  • Tyrosine phosphorylation of VCP, the mammalian homologue of the Saccharomyces cerevisiae CDC48 protein, is unusually sensitive to stimulation by sodium vanadate and hydrogen peroxide [32].
  • A tyrosine phosphatase inhibitor, sodium pervanadate, induced two GAS-binding complexes related to MGF and STAT1 [33].
  • Similarly treatment of GEO cells with a phosphatase inhibitor (sodium vanadate) caused a dose-dependent increase in ERK1 activity which paralleled increased cell surface binding of urokinase [34].

Analytical, diagnostic and therapeutic context of SODIUM VANADATE

  • Western blot analysis showed that the immunoreactivity of a M(r) 170,000 band of cell lysate to antiphosphotyrosine antibody was reduced by SAGP, and the effect was abolished by sodium orthovanadate [1].
  • Sodium orthovanadate (Na3 VO4) is identical with the purified inhibitor with respect to ultraviolet absorbance, migration on thin layer chromatography, and inhibition of (Na,K)-ATPase [35].
  • An inhibitor generated by the 0-h extract after treatment with a phosphatase inhibited E2F complex formation by the untreated 0-h extract in the presence of phosphatase inhibitors, okadaic acid and sodium vanadate [36].
  • In this study, activation of hepatic kinases, phosphatases, and DNA-binding activity of AP-1 was examined after intraperitoneal injections of either EGF or sodium orthovanadate into mice [37].
  • The renal effects of sodium vanadate (Na3VO4), an inhibitor of sodium-potassium-ATPase recently shown to be a potent diuretic, were studied by using clearance and micropuncture techniques in nondiuretic anesthetized rats [38].


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  2. Carcinoembryonic antigen cell adhesion molecule 1 directly associates with cytoskeleton proteins actin and tropomyosin. Schumann, D., Chen, C.J., Kaplan, B., Shively, J.E. J. Biol. Chem. (2001) [Pubmed]
  3. The stimulation of pp60v-src kinase activity by vanadate in intact cells accompanies a new phosphorylation state of the enzyme. Brown, D.J., Gordon, J.A. J. Biol. Chem. (1984) [Pubmed]
  4. Neuroprotective effect of sodium orthovanadate on delayed neuronal death after transient forebrain ischemia in gerbil hippocampus. Kawano, T., Fukunaga, K., Takeuchi, Y., Morioka, M., Yano, S., Hamada, J., Ushio, Y., Miyamoto, E. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  5. Effects of chromium on basal and insulin-induced tyrosine phosphorylation in H4 hepatoma cells: comparison with phorbol-12-myristate-13-acetate and sodium orthovanadate. Yurkow, E.J., Kim, G. Mol. Pharmacol. (1995) [Pubmed]
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  7. Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. Pende, D., Parolini, S., Pessino, A., Sivori, S., Augugliaro, R., Morelli, L., Marcenaro, E., Accame, L., Malaspina, A., Biassoni, R., Bottino, C., Moretta, L., Moretta, A. J. Exp. Med. (1999) [Pubmed]
  8. CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation. Law, C.L., Sidorenko, S.P., Chandran, K.A., Zhao, Z., Shen, S.H., Fischer, E.H., Clark, E.A. J. Exp. Med. (1996) [Pubmed]
  9. CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated protein. Faris, M., Gaskin, F., Parsons, J.T., Fu, S.M. J. Exp. Med. (1994) [Pubmed]
  10. A phosphatase activity present in peripheral blood myeloid cells of chronic myelogenous leukemia patients but not normal individuals alters nuclear protein binding to transcriptional enhancers of interferon-inducible genes. Seong, D.C., Sims, S., Johnson, E., Howard, O.M., Reiter, B., Hester, J., Talpaz, M., Kantarjian, H., Deisseroth, A. J. Clin. Invest. (1990) [Pubmed]
  11. Vanadyl sulfate-stimulated glycogen synthesis is associated with activation of phosphatidylinositol 3-kinase and is independent of insulin receptor tyrosine phosphorylation. Pandey, S.K., Anand-Srivastava, M.B., Srivastava, A.K. Biochemistry (1998) [Pubmed]
  12. Protein tyrosine phosphorylation in the cyanobacterium Anabaena sp. strain PCC 7120. McCartney, B., Howell, L.D., Kennelly, P.J., Potts, M. J. Bacteriol. (1997) [Pubmed]
  13. Experimental colitis modulates the functional properties of NMDA receptors in dorsal root ganglia neurons. Li, J., McRoberts, J.A., Ennes, H.S., Trevisani, M., Nicoletti, P., Mittal, Y., Mayer, E.A. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  14. Down-regulation of PTEN by sodium orthovanadate inhibits ASK1 activation via PI3-K/Akt during cerebral ischemia in rat hippocampus. Wu, D.N., Pei, D.S., Wang, Q., Zhang, G.Y. Neurosci. Lett. (2006) [Pubmed]
  15. Microtubule depolymerization promotes particle and chromosome movement in vitro. Coue, M., Lombillo, V.A., McIntosh, J.R. J. Cell Biol. (1991) [Pubmed]
  16. Tyrosine dephosphorylation of nuclear proteins mimics transforming growth factor beta 1 stimulation of alpha 2(I) collagen gene expression. Greenwel, P., Hu, W., Kohanski, R.A., Ramirez, F. Mol. Cell. Biol. (1995) [Pubmed]
  17. Regulation of pp90rsk phosphorylation and S6 phosphotransferase activity in Swiss 3T3 cells by growth factor-, phorbol ester-, and cyclic AMP-mediated signal transduction. Chen, R.H., Chung, J., Blenis, J. Mol. Cell. Biol. (1991) [Pubmed]
  18. Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p53. Morita, A., Zhu, J., Suzuki, N., Enomoto, A., Matsumoto, Y., Tomita, M., Suzuki, T., Ohtomo, K., Hosoi, Y. Cell Death Differ. (2006) [Pubmed]
  19. The OST4 gene of Saccharomyces cerevisiae encodes an unusually small protein required for normal levels of oligosaccharyltransferase activity. Chi, J.H., Roos, J., Dean, N. J. Biol. Chem. (1996) [Pubmed]
  20. Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: role of membrane phosphatidylserine. Sambrano, G.R., Steinberg, D. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  21. Effect of vanadate on intracellular distribution and function of 10-nm filaments. Wang, E., Choppin, P.W. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  22. In vivo effect of sodium orthovanadate on pp60c-src kinase. Ryder, J.W., Gordon, J.A. Mol. Cell. Biol. (1987) [Pubmed]
  23. A soluble adenosine triphosphate-dependent proteolytic system in human peripheral red blood cells. Rieder, R.F., Ibrahim, A., Etlinger, J.D. Blood (1986) [Pubmed]
  24. The grb2/mek pathway represses nanog in murine embryonic stem cells. Hamazaki, T., Kehoe, S.M., Nakano, T., Terada, N. Mol. Cell. Biol. (2006) [Pubmed]
  25. A stimulated S6 kinase from rat liver: identity with the mitogen activated S6 kinase of 3T3 cells. Kozma, S.C., Lane, H.A., Ferrari, S., Luther, H., Siegmann, M., Thomas, G. EMBO J. (1989) [Pubmed]
  26. Vanadium ions stimulate DNA synthesis in Swiss mouse 3T3 and 3T6 cells. Smith, J.B. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  27. Tyrosine phosphorylation within the amino-terminal domain of pp60c-src molecules associated with polyoma virus middle-sized tumor antigen. Yonemoto, W., Jarvis-Morar, M., Brugge, J.S., Bolen, J.B., Israel, M.A. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  28. Interleukin-3, GM-CSF, and TPA induce distinct phosphorylation events in an interleukin 3-dependent multipotential cell line. Sorensen, P.H., Mui, A.L., Murthy, S.C., Krystal, G. Blood (1989) [Pubmed]
  29. Stat5 constitutive activation rescues defects in spinal muscular atrophy. Ting, C.H., Lin, C.W., Wen, S.L., Hsieh-Li, H.M., Li, H. Hum. Mol. Genet. (2007) [Pubmed]
  30. Requirement of Tyr-992 and Tyr-1173 in phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2. Sturla, L.M., Amorino, G., Alexander, M.S., Mikkelsen, R.B., Valerie, K., Schmidt-Ullrichr, R.K. J. Biol. Chem. (2005) [Pubmed]
  31. Hepatitis C virus and HIV envelope proteins collaboratively mediate interleukin-8 secretion through activation of p38 MAP kinase and SHP2 in hepatocytes. Balasubramanian, A., Ganju, R.K., Groopman, J.E. J. Biol. Chem. (2003) [Pubmed]
  32. Tyrosine phosphorylation of VCP, the mammalian homologue of the Saccharomyces cerevisiae CDC48 protein, is unusually sensitive to stimulation by sodium vanadate and hydrogen peroxide. Schulte, R.J., Campbell, M.A., Fischer, W.H., Sefton, B.M. J. Immunol. (1994) [Pubmed]
  33. Activation of STAT factors by prolactin, interferon-gamma, growth hormones, and a tyrosine phosphatase inhibitor in rabbit primary mammary epithelial cells. Tourkine, N., Schindler, C., Larose, M., Houdebine, L.M. J. Biol. Chem. (1995) [Pubmed]
  34. Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade. Lengyel, E., Wang, H., Gum, R., Simon, C., Wang, Y., Boyd, D. Oncogene (1997) [Pubmed]
  35. Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle. Cantley, L.C., Josephson, L., Warner, R., Yanagisawa, M., Lechene, C., Guidotti, G. J. Biol. Chem. (1977) [Pubmed]
  36. Protein phosphorylation required for the formation of E2F complexes regulates N-myc transcription during differentiation of human embryonal carcinoma cells. Hara, E., Okamoto, S., Nakada, S., Taya, Y., Sekiya, S., Oda, K. Oncogene (1993) [Pubmed]
  37. Treatment of mice with EGF and orthovanadate activates cytoplasmic and nuclear MAPK, p70S6k, and p90rsk in the liver. Ostrowski, J., Woszczyński, M., Kowalczyk, P., Trzeciak, L., Hennig, E., Bomsztyk, K. J. Hepatol. (2000) [Pubmed]
  38. Effects of sodium orthovanadate on whole kidney and single nephron function. Higashi, Y., Bello-Reuss, E. Kidney Int. (1980) [Pubmed]
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